Is Chemical Reprogramming Cocktails legal in Canada?

Combinations of small molecules that replace the gene therapy in reprogramming. All of the ageing work is in cells in a dish, plus one lifespan result in a nematode.

Every reprogramming approach with an ageing result behind it delivers transcription factors with a virus. Chemical reprogramming is the attempt to do the same thing with small molecules, which would remove the viral vector, the genetic cassette and the manufacturing problem in one step.

Mechanism: In vitro, in human cells. Small-molecule combinations induce an intermediate plastic state that permits reprogramming without transcription-factor delivery; inhibition of the JNK pathway was identified as necessary to induce that plasticity by suppressing pro-inflammatory pathways.

Regulatory history: Not approved anywhere. There is no registered human trial of a reprogramming cocktail for any ageing indication. These are laboratory reagents.

Authorises drugs for sale through a Notice of Compliance and Drug Identification Number. A compound that is not authorised for sale cannot lawfully be sold for human use, and personal importation of prescription drugs is limited.

The classification above is the The Longevity Archive reading of Health Canada, Health Products and Food Branch listings for Chemical Reprogramming Cocktails at the reviewed date, not a legal opinion. Rules change, and importing, prescribing and possessing a compound can each be treated differently. Check the regulator directly before acting on anything here.