Is Chemical Reprogramming Cocktails legal in the United Kingdom?

Combinations of small molecules that replace the gene therapy in reprogramming. All of the ageing work is in cells in a dish, plus one lifespan result in a nematode.

Every reprogramming approach with an ageing result behind it delivers transcription factors with a virus. Chemical reprogramming is the attempt to do the same thing with small molecules, which would remove the viral vector, the genetic cassette and the manufacturing problem in one step.

Mechanism: In vitro, in human cells. Small-molecule combinations induce an intermediate plastic state that permits reprogramming without transcription-factor delivery; inhibition of the JNK pathway was identified as necessary to induce that plasticity by suppressing pro-inflammatory pathways.

Regulatory history: Not approved anywhere. There is no registered human trial of a reprogramming cocktail for any ageing indication. These are laboratory reagents.

Licenses medicines for the UK market. A compound without a marketing authorisation is an unlicensed medicine, which can only lawfully be supplied for human use through a prescriber under the specials scheme, not sold as a research product.

The classification above is the The Longevity Archive reading of Medicines and Healthcare products Regulatory Agency listings for Chemical Reprogramming Cocktails at the reviewed date, not a legal opinion. Rules change, and importing, prescribing and possessing a compound can each be treated differently. Check the regulator directly before acting on anything here.