Is Chemical Reprogramming Cocktails legal in Australia?

Combinations of small molecules that replace the gene therapy in reprogramming. All of the ageing work is in cells in a dish, plus one lifespan result in a nematode.

Every reprogramming approach with an ageing result behind it delivers transcription factors with a virus. Chemical reprogramming is the attempt to do the same thing with small molecules, which would remove the viral vector, the genetic cassette and the manufacturing problem in one step.

Mechanism: In vitro, in human cells. Small-molecule combinations induce an intermediate plastic state that permits reprogramming without transcription-factor delivery; inhibition of the JNK pathway was identified as necessary to induce that plasticity by suppressing pro-inflammatory pathways.

Regulatory history: Not approved anywhere. There is no registered human trial of a reprogramming cocktail for any ageing indication. These are laboratory reagents.

Registers or lists therapeutic goods on the ARTG and schedules substances in the Poisons Standard. Many peptides are Schedule 4 (prescription only), so possession without a prescription and personal importation are restricted even when no product is registered.

The classification above is the The Longevity Archive reading of Therapeutic Goods Administration listings for Chemical Reprogramming Cocktails at the reviewed date, not a legal opinion. Rules change, and importing, prescribing and possessing a compound can each be treated differently. Check the regulator directly before acting on anything here.