Is GIP legal in the United States?

GIP is one of two gut hormones that tell your pancreas to release insulin after a meal. It is the G in tirzepatide and the other drugs that hit two or three hormone targets. In people, drugs that switch its receptor on and drugs that block it have both caused weight loss. Nobody has explained why.

GIP is a hormone your gut makes when you eat. It comes from cells in the upper small intestine.

How it works: GIP docks on its own receptor. In the insulin-making cells of the pancreas, that boosts insulin release when blood sugar is high.

Approval history: Not an approved drug, and not used as a treatment. Drugs that work on its receptor are approved, including tirzepatide.

Approves prescription drugs, each for a named use. It also acts against unapproved products, including peptides sold online. Compounding pharmacies, which mix drugs to order, may make some compounds with a prescription. That only applies when the FDA puts the compound in a category of bulk ingredients it allows.

The legal category above is how The Longevity Archive reads U.S. Food and Drug Administration listings for GIP on the reviewed date. It is not a legal opinion. Rules change. Bringing a compound into the country, prescribing it and owning it can each be treated differently. Check with the agency before you act on anything here.

Check FDA directly

Whether GIP is banned in sport is set by the World Anti-Doping Code and by military rules, not by its legal status in the United States. Before you compete or get tested, look up GIP by name on the Prohibited List, or look up a named product in Global DRO. Under the World Anti-Doping Code, category S0 bans, at all times, any drug-like substance that meets two tests. No other section of the List covers it. And no government health regulator anywhere has a current approval for it as a treatment in people. Many substances that are approved somewhere are banned by name in another section. So approval does not mean a substance is allowed in sport.

• WADA Prohibited List
• Global DRO (check a named product)
• USADA (US athletes)
• Operation Supplement Safety (US service members)

The rules you compete or serve under decide this, not this page.