Is Senolytic CAR T cells legal in Canada?

Living immune cells, called T cells, engineered to find and kill worn-out 'zombie' cells by a marker on their surface called uPAR. Every result is in mice. No human study of this for ageing or zombie cells is registered anywhere.

This is one of the cleverest ideas in the senolytic field, and it has never been given to a person for this purpose. Senolytic pills work by pushing already-stressed zombie cells over the edge so they die.

How it works: uPAR is a protein anchored on the outside of cells. It goes up a lot when cells turn into zombie cells, so it can serve as a tag for them.

Approval history: No CAR T product that clears worn-out (senescent) cells is approved, and none is in a registered human trial for ageing or worn-out cells. CAR T therapy in general is approved in the United States for certain blood cancers. That is a different target, a different patient and a different weighing of risk.

Allows a drug to be sold by issuing a Notice of Compliance and a Drug Identification Number (DIN). A compound that is not allowed for sale cannot legally be sold for use in people. Bringing in prescription drugs for your own use is also limited.

The legal category above is how The Longevity Archive reads Health Canada, Health Products and Food Branch listings for Senolytic CAR T cells on the reviewed date. It is not a legal opinion. Rules change. Bringing a compound into the country, prescribing it and owning it can each be treated differently. Check with the agency before you act on anything here.

Check Health Canada directly

Whether Senolytic CAR T cells is banned in sport is set by the World Anti-Doping Code and by military rules, not by its legal status in Canada. Before you compete or get tested, look up Senolytic CAR T cells by name on the Prohibited List, or look up a named product in Global DRO. Under the World Anti-Doping Code, category S0 bans, at all times, any drug-like substance that meets two tests. No other section of the List covers it. And no government health regulator anywhere has a current approval for it as a treatment in people. Many substances that are approved somewhere are banned by name in another section. So approval does not mean a substance is allowed in sport.

• WADA Prohibited List
• Global DRO (check a named product)
• USADA (US athletes)
• Operation Supplement Safety (US service members)

The rules you compete or serve under decide this, not this page.