Is FOXO4-DRI legal in Canada?

An experimental peptide that kills worn-out cells in animal studies. It has not been tested in people.

FOXO4-DRI is a designed peptide aimed at senescent cells. These are old, worn-out cells that stop dividing but do not die.

How it works: In worn-out cells, it breaks the hold FOXO4 has on p53. That frees p53 to make those cells die off.

Approval history: Not FDA-approved; experimental

Allows a drug to be sold by issuing a Notice of Compliance and a Drug Identification Number (DIN). A compound that is not allowed for sale cannot legally be sold for use in people. Bringing in prescription drugs for your own use is also limited.

The legal category above is how The Longevity Archive reads Health Canada, Health Products and Food Branch listings for FOXO4-DRI on the reviewed date. It is not a legal opinion. Rules change. Bringing a compound into the country, prescribing it and owning it can each be treated differently. Check with the agency before you act on anything here.

Check Health Canada directly

Whether FOXO4-DRI is banned in sport is set by the World Anti-Doping Code and by military rules, not by its legal status in Canada. Before you compete or get tested, look up FOXO4-DRI by name on the Prohibited List, or look up a named product in Global DRO. Under the World Anti-Doping Code, category S0 bans, at all times, any drug-like substance that meets two tests. No other section of the List covers it. And no government health regulator anywhere has a current approval for it as a treatment in people. Many substances that are approved somewhere are banned by name in another section. So approval does not mean a substance is allowed in sport.

• WADA Prohibited List
• Global DRO (check a named product)
• USADA (US athletes)
• Operation Supplement Safety (US service members)

The rules you compete or serve under decide this, not this page.