Head to head
FOXO4-DRI against Fisetin
An experimental senolytic peptide against a flavonoid sold in capsules. FOXO4-DRI's record is animal work on selective clearance of senescent cells; fisetin has small human trials that have not yet shown that clearing cells changes anything.
Column A
FOXO4-DRIFOXO4-DRI (senolytic peptide)
An experimental senolytic peptide that selectively triggers death of senescent cells in animal studies.
Column B
FisetinFisetin (senolytic flavonoid)
A plant flavonoid and leading natural senolytic. One mouse study reported extended lifespan; the multi-site programme built to replicate such results found no effect.
Side by side, on the facts we can check
| Attribute | FOXO4-DRI | Fisetin |
|---|---|---|
| Category | Anti-aging | Longevity |
| FDA status | Not FDA-approved; experimental | Sold as a supplement; in clinical trials for aging |
| Half-life | Short | ~1-3 hours |
| Molecular weight | ~5,200 Da | 286.2 Da |
| Mechanism | Disrupts the FOXO4-p53 interaction selectively in senescent cells, allowing p53 to initiate targeted apoptosis of those cells. | Selectively triggers death of senescent cells, reducing the inflammatory signals they release. |
| Human studies cited | 0 | 1 |
| Legal status, US | Not approved; research use only | Sold as a dietary supplement |
Frequently asked questions
What is the difference between FOXO4-DRI and Fisetin?
FOXO4-DRI: An experimental senolytic peptide that selectively triggers death of senescent cells in animal studies. Fisetin: A plant flavonoid and leading natural senolytic. One mouse study reported extended lifespan; the multi-site programme built to replicate such results found no effect.
Which has stronger research evidence, FOXO4-DRI or Fisetin?
This database does not grade compounds. It counts what was run in people: 0 of the 2 studies cited on the FOXO4-DRI profile were human work, against 1 of 3 for Fisetin. Those counts are of our own citation lists and understate any larger literature, and neither is a recommendation.
Are FOXO4-DRI and Fisetin FDA-approved?
FOXO4-DRI: Not FDA-approved; experimental. Fisetin: Sold as a supplement; in clinical trials for aging.
Related posts
Blog articles that cover FOXO4-DRI or Fisetin, newest first.
- Longevity / Sep 8, 2026 / 12 minPeptides for Longevity: What the Evidence Actually Shows in 2026
- Longevity / Sep 8, 2026 / 9 minSenolytics in 2026: Dasatinib plus Quercetin, Fisetin, and What Human Trials Have Shown
- Longevity / Sep 8, 2026 / 9 minThe Rapamycin Dosing Debate: What PEARL Tested, the Bioavailability Problem, and What Is Unproven
- Longevity / Sep 8, 2026 / 8 minKlotho Explained: Protein, Peptide, Gene Therapy or Supplement?
Reviewed Sep 2026. This page sets two published records side by side. It is educational, it is not medical advice, and it contains no dosing protocols or recommendations for personal use.