Head to head
GLP-2 against Teduglutide
The gut hormone and the drug built from it. Native GLP-2 is degraded within minutes by DPP-4, and teduglutide exists because a single amino acid substitution blocks that.
Column A
GLP-2Glucagon-Like Peptide-2 (native intestinal hormone)
A natural gut hormone that promotes growth and repair of the intestinal lining, the basis for the drug teduglutide.
Column B
TeduglutideTeduglutide (GLP-2 analogue)
An FDA-approved GLP-2 analogue that promotes intestinal growth in short bowel syndrome, reducing dependence on IV nutrition.
Side by side, on the facts we can check
| Attribute | GLP-2 | Teduglutide |
|---|---|---|
| Category | Metabolic | Metabolic |
| FDA status | The hormone itself is not a medicine. Its analogue teduglutide (Gattex) is an FDA-approved prescription drug for short bowel syndrome. | FDA-approved (Gattex) for short bowel syndrome |
| Half-life | ~7 minutes (native) | ~2 hours |
| Molecular weight | 3,766.1 Da | 3,752.1 Da |
| Mechanism | Activates GLP-2 receptors to stimulate intestinal mucosal growth, reduce cell death, and improve gut barrier function. | Activates GLP-2 receptors in the gut to stimulate growth of the intestinal mucosa and improve nutrient absorption. |
| Human studies cited | 0 | 3 |
| Legal status, US | Not a medicine; endogenous signalling molecule | FDA-approved, prescription only |
Frequently asked questions
What is the difference between GLP-2 and Teduglutide?
GLP-2: A natural gut hormone that promotes growth and repair of the intestinal lining, the basis for the drug teduglutide. Teduglutide: An FDA-approved GLP-2 analogue that promotes intestinal growth in short bowel syndrome, reducing dependence on IV nutrition.
Which has stronger research evidence, GLP-2 or Teduglutide?
This database does not grade compounds. It counts what was run in people: 0 of the 2 studies cited on the GLP-2 profile were human work, against 3 of 3 for Teduglutide. Those counts are of our own citation lists and understate any larger literature, and neither is a recommendation.
Are GLP-2 and Teduglutide FDA-approved?
GLP-2: The hormone itself is not a medicine. Its analogue teduglutide (Gattex) is an FDA-approved prescription drug for short bowel syndrome.. Teduglutide: FDA-approved (Gattex) for short bowel syndrome.
Related posts
Blog articles that cover GLP-2 or Teduglutide, newest first.
Reviewed Sep 2026. This page sets two published records side by side. It is educational, it is not medical advice, and it contains no dosing protocols or recommendations for personal use.