Peptide finder

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Pick as many as you like. The number on each one is how many people it has been measured in across the whole archive. So you can see where the evidence is before you choose.

1. 01NiacinSupplementStrong. At least two finished studies in people, and at least 1,000 people who took it. 2 completed trials, 29,087 people given it.7 reported

   29,087 people2 studies

   • Niacin failed on top of a statin and it harmed people. 25,673 adults with vascular disease took niacin with laropiprant or a dummy pill for close to four years. Cholesterol numbers moved the right way. Major vascular events did not, at about 13 in every hundred in each group. Treatment caused extra diabetes, extra...

     New England Journal of Medicine, 2014 · 25,673 people

   • Niacin improved the blood numbers and did nothing for patients already on a statin. 3,414 people with established artery disease took slow release niacin or a dummy pill on top of their statin. Good cholesterol rose, triglycerides fell and bad cholesterol fell. Heart attacks, strokes and cardiac deaths came out...

     New England Journal of Medicine, 2011 · 3,414 people

2. 02SimvastatinSmall moleculeStrong. At least two finished studies in people, and at least 1,000 people who took it. 2 completed trials, 24,980 people given it.6 reported

   20,536 people1 study

   • The benefit held even in people whose cholesterol already looked normal. 20,536 UK adults aged 40 to 80 with clogged arteries or diabetes were split by chance. One group took 40 mg of simvastatin a day, the other took a dummy pill. 14.7 percent of the dummy group died of any cause, against 12.9 percent on the drug....

     Lancet, 2002 · 20,536 people

3. 03EnlicitidePeptideStrong. At least two finished studies in people, and at least 1,000 people who took it. 3 completed trials, 2,909 people given it.2 reported

   2,909 people1 study

   • A PCSK9 drug you swallow works, and until now this kind of drug needed a shot. 2,909 people took enlicitide pills or a dummy pill for a year. Their LDL cholesterol fell by about 57 percent, while the dummy group drifted up 3 percent. Other harmful blood fats improved too. This study measured cholesterol, not heart...

     New England Journal of Medicine, 2026 · 2,909 people

4. 04NattokinaseBiologicStrong. At least two finished studies in people, and at least 1,000 people who took it. 9 completed trials, 1,795 people given it.6 reported

   225 people2 studies1 found nothing

   • In a better built trial, nattokinase alone moved one blood fat and nothing else. 178 patients with stable heart disease, already on their usual medicines, took nattokinase, red yeast rice, both, or a dummy pill for 90 days. Nattokinase alone lowered LDL, the harmful cholesterol, compared with the dummy. Total...

     Frontiers in Nutrition, 2024 · 178 people

   • found nothingOn its own, nattokinase did nothing to cholesterol. 47 patients with high cholesterol took nattokinase alone, nattokinase with red yeast rice, or a dummy, for six months. The nattokinase-only group came out no different from the dummy. The combination improved every blood fat from the first month onwards. That...

     Asia Pacific Journal of Clinical Nutrition, 2009 · 47 people

5. 05ResveratrolSupplementModerate. At least one finished study in people, and at least 100 people who took it. 14 completed trials, 403 people given it.7 reported

   192 people1 study1 found nothing

   • found nothingThe longest and largest diabetes trial of resveratrol found nothing that counted. 192 patients took 40 mg, 500 mg or a dummy pill every day for six months. An inflammation marker fell further on resveratrol, but not by enough to call real. Weight, waist, blood pressure, blood sugar, insulin and a string of other...

     Pharmacological Research, 2016 · 192 people

6. 06BetaineSupplementModerate. At least one finished study in people, and at least 100 people who took it. 3 completed trials, 170 people given it.4 reported

   151 people1 study1 found nothing

   • found nothingBetaine lowers homocysteine and raises bad cholesterol at the same time. Blood fat results were pooled from four studies, three of them betaine trials covering 151 people. At 6 grams a day for six weeks, bad cholesterol rose by 0.36 units and triglycerides by 0.14. Lower doses raised bad cholesterol too, by less. The...

     PLoS Medicine, 2005 · 151 people

7. 07BerberineSupplementModerate. At least one finished study in people, and at least 100 people who took it. 3 completed trials, 186 people given it.4 reported

   116 people1 study

   • A larger diabetes study than the famous 36 person one. 116 adults with type 2 diabetes and high blood fats took 1 gram of berberine a day, or a dummy pill, for three months. Fasting sugar fell from 7.0 to 5.6. HbA1c fell from 7.5 to 6.6 percent. Triglycerides, total cholesterol and LDL fell too. It measured blood...

     Journal of Clinical Endocrinology and Metabolism, 2008 · 116 people

8. 08CurcuminSupplementModerate. At least one finished study in people, and at least 100 people who took it. 3 completed trials, 195 people given it.5 reported

   100 people1 study

   • A high-absorption mix of curcumin and piperine improved blood fats in people who already had metabolic syndrome. 100 people took 1000 mg a day of the mix, or a dummy pill, for 8 weeks on top of usual care. LDL, triglycerides and total cholesterol fell, and HDL rose. This tested one specific form on blood fats. It is...

     Complementary Therapies in Medicine, 2014 · 100 people

9. 09PterostilbeneSupplementLimited. People have taken it in a published study, but fewer than 100 of them. 1 completed trial, 80 people given it.4 reported

   80 people1 study

   • It pushed blood pressure down and bad cholesterol up. 80 adults with raised cholesterol took pterostilbene at 125 mg twice a day, at 50 mg twice a day, at 50 mg with grape extract, or a dummy, for 6 to 8 weeks. On pterostilbene alone, bad cholesterol rose 17.1 units. Adding grape extract removed that rise. On the high...

     Evidence-Based Complementary and Alternative Medicine, 2014 · 80 people

10. 10DanazolHormoneLimited. People have taken it in a published study, but fewer than 100 of them. 3 completed trials, 63 people given it.5 reported

    36 people1 study

    • This is what danazol costs, measured in a different illness. 36 patients with acquired aplastic anaemia took danazol on its own, 10 mg per kilogram a day up to a cap of 600 mg. After six months, good cholesterol had fallen 30 percent and bad cholesterol had risen 11 percent. The size of the heart's main pumping...

      Blood Cells, Molecules and Diseases, 2025 · 36 people

11. 11PQQSupplementModerate. At least one finished study in people, and at least 100 people who took it. 3 completed trials, 116 people given it.5 reported

    29 people1 study1 found nothing

    • found nothingPQQ did not move triglycerides, which is what it was given for. 29 healthy Japanese adults aged 40 to 57 took 20 mg a day or a dummy for twelve weeks, and nobody involved knew which. Triglycerides came out unchanged. Bad cholesterol dipped slightly in the PQQ group, and dipped more in the few people whose level...

      Journal of Nutritional Science and Vitaminology, 2015 · 29 people

12. 12DHEAHormoneModerate. At least one finished study in people, and at least 100 people who took it. 3 completed trials, 267 people given it.5 reported

    24 people1 study

    • In women whose adrenal glands make no DHEA, replacing it helped mood and sexual interest. 24 women took DHEA for four months and a dummy pill for four months. It is a study of people who lack the hormone, not of ageing.

      The New England Journal of Medicine, 1999 · 24 people

13. 13NMNSupplementLimited. People have taken it in a published study, but fewer than 100 of them. 4 completed trials, 94 people given it.6 reported

    number of people not given1 study1 found nothing

    • found nothingA high dose NMN tablet raised NAD in the blood and moved weight and cholesterol, but not muscle. 30 overweight or obese adults took MIB-626, 1000 mg twice a day, or a dummy pill, for 28 days. Weight fell 1.9 kg. The lower blood pressure number and LDL cholesterol fell too. Strength, tiredness, fitness and stair...

      Journal of Clinical Endocrinology and Metabolism, 2023 · number of people not given

14. 14CardarineSmall moleculePreliminary. Studied in people, but no published study has had people take it. 1 registered with no result.7 reported

    number of people not given1 study

    • The biggest human trial moved blood fats the right way, and the story still ends badly. 268 people with low good cholesterol took one of three doses or a dummy for 12 weeks. Good cholesterol rose by about a sixth, triglycerides fell by about the same, and another harmful cholesterol marker fell too. Twelve weeks is...

      Arteriosclerosis, Thrombosis, and Vascular Biology, 2012 · number of people not given

15. 15EpicatechinSupplementLimited. People have taken it in a published study, but fewer than 100 of them. 4 completed trials, 44 people given it.1 reported

    number of people not given1 study1 found nothing

    • found nothingA food-sized dose of pure epicatechin did nothing. 48 overweight or obese non-smokers with features of metabolic syndrome took 25 mg a day for two weeks, and each took a dummy for two weeks as well, in turn. Nothing moved: not blood pressure, glucose, insulin, triglycerides, or any cholesterol measure. The authors...

      American Journal of Clinical Nutrition, 2018 · number of people not given

16. 16SRT2104Small moleculeLimited. People have taken it in a published study, but fewer than 100 of them. 1 completed trial, none stating how many people.

    number of people not given1 study

    • The thing this trial set out to measure did not change. Twenty four otherwise healthy smokers took a purpose built sirtuin activating drug for four weeks and a dummy for four weeks, without knowing the order. Blood vessel function and platelet behaviour were no different on the drug. Cholesterol and triglycerides did...

      Journal of the American Heart Association, 2013 · number of people not given

17. 17MIB-626SupplementModerate. At least one finished study in people, and at least 100 people who took it. 4 completed trials, 107 people given it.1 reported

    number of people not given1 study1 found nothing

    • found nothingThe tablet moved some body measurements and left every measure of physical function untouched. 30 overweight or obese adults aged 45 and over took MIB-626 or a dummy tablet for four weeks. Weight fell by about two kilograms. Blood pressure and cholesterol both came down. Strength, stamina, how quickly muscles tired...

      Journal of Clinical Endocrinology and Metabolism, 2023 · number of people not given

18. 18CJC-1295PeptideLimited. People have taken it in a published study, but fewer than 100 of them. 2 completed trials, none stating how many people.9 reported

    11 people1 study

    • This looked at proteins in the blood, not at anything a person would notice. 11 healthy young men gave blood before a CJC-1295 injection and again a week later. Five protein spots shifted: two fell and three rose. That is a signal that something changed in the blood. It is not weight, muscle, strength, sleep or any...

      Growth Hormone and IGF Research, 2009 · 11 people

19. 19MCT oilSupplementModerate. At least one finished study in people, and at least 100 people who took it. 1 completed trial, 152 people given it.6 reported

    number of people not given0 studies

    • In mice. Five supplements were mixed into the food from 4 months of age, at three labs: resveratrol, green tea extract, curcumin, oxaloacetic acid and MCT oil. None of them changed how long male or female mice lived.

      Journals of Gerontology Series A, 2013 · number of people not given

20. 20EnobosarmSmall moleculeModerate. At least one finished study in people, and at least 100 people who took it. 1 completed trial, 159 people given it.5 reported

    number of people not given0 studies
21. 21Therapeutic Plasma ExchangeProcedureModerate. At least one finished study in people, and at least 100 people who took it. 5 completed trials, 389 people given it.6 reported

    number of people not given0 studies
22. 22OxandroloneHormonePreliminary. Studied in people, but no published study has had people take it. 1 human study where nobody was given it.5 reported

    number of people not given0 studies
23. 23TestosteroneHormoneModerate. At least one finished study in people, and at least 100 people who took it. 1 completed trial, 5,246 people given it.10 reported

    number of people not given0 studies
24. 24PsylliumSupplementNone. No study cited on this page yet. no study cited on this page yet.2 reported

    number of people not given0 studies