Is CMS-121 legal in the United States?

CMS-121 is a lab-made cousin of fisetin, from the Salk Institute. In mouse models of Alzheimer's it improved memory and cut fat damage in the brain. It is still in animal safety testing, yet it is already sold as a research chemical.

CMS-121 was built to be stronger than fisetin and to get into the brain better. In mouse models of Alzheimer's, it kept memory intact and cut damage to fats in the brain.

How it works: It blocks an enzyme that makes fatty acids and cuts damage to fats in brain cells. In ageing brains, that seems to calm inflammation and keep brain cells' energy supply working.

Approval history: Animal or lab only; not approved

Approves prescription drugs, each for a named use. It also acts against unapproved products, including peptides sold online. Compounding pharmacies, which mix drugs to order, may make some compounds with a prescription. That only applies when the FDA puts the compound in a category of bulk ingredients it allows.

The legal category above is how The Longevity Archive reads U.S. Food and Drug Administration listings for CMS-121 on the reviewed date. It is not a legal opinion. Rules change. Bringing a compound into the country, prescribing it and owning it can each be treated differently. Check with the agency before you act on anything here.

Check FDA directly

Whether CMS-121 is banned in sport is set by the World Anti-Doping Code and by military rules, not by its legal status in the United States. Before you compete or get tested, look up CMS-121 by name on the Prohibited List, or look up a named product in Global DRO. Under the World Anti-Doping Code, category S0 bans, at all times, any drug-like substance that meets two tests. No other section of the List covers it. And no government health regulator anywhere has a current approval for it as a treatment in people. Many substances that are approved somewhere are banned by name in another section. So approval does not mean a substance is allowed in sport.

• WADA Prohibited List
• Global DRO (check a named product)
• USADA (US athletes)
• Operation Supplement Safety (US service members)

The rules you compete or serve under decide this, not this page.