Legal status · United Kingdom
Is MET-233i legal in the United Kingdom?
No. MET-233i is not approved for any medical use in the United Kingdom; its classification is "Investigational, not licensed". Lawful access is limited to registered clinical trials. "Research use only" labeling on vials sold online does not make human use lawful. Human evidence to date: Preliminary.
MET-233i in the United Kingdom at a glance
| Classification | Investigational, not licensed |
|---|---|
| MHRA approval status | Not approved by MHRA; investigational |
| Evidence level | Preliminary (research strength: Preliminary) |
| Reviewed | Sep 2026 |
Classification and note come from the MET-233i profile, checked against Medicines and Healthcare products Regulatory Agency (MHRA) listings at the reviewed date.
What this means
- 01
MET-233i is being studied in registered clinical trials but has not received MHRA marketing approval in the United Kingdom.
- 02
Lawful human access is limited to trial participation or a formal early-access scheme where one exists; there is no pharmacy product to prescribe.
- 03
Vials sold online "for research use only" are not trial material, and that label does not make human use lawful.
What MET-233i is
Pfizer's monthly amylin analog (from Metsera) with a 19-day half-life, being co-formulated with berobenatide into a once-monthly GLP-1 plus amylin combination.
MET-233i shares the albumin-binding platform used by berobenatide. 4% placebo-subtracted weight loss by day 36 as a monotherapy, and Pfizer's 2026 pipeline lists the combination with berobenatide in Phase 2.
Mechanism: Ultra-long-acting amylin receptor agonism, designed for monthly dosing alone or with a GLP-1 agonist.
Regulatory history: Investigational; Phase 2 (combination)
How MHRA treats this kind of product
Licenses medicines for the UK market. A compound without a marketing authorisation is an unlicensed medicine, which can only lawfully be supplied for human use through a prescriber under the specials scheme, not sold as a research product.
The classification above is the The Longevity Archive reading of Medicines and Healthcare products Regulatory Agency listings for MET-233i at the reviewed date, not a legal opinion. Rules change, and importing, prescribing and possessing a compound can each be treated differently. Check the regulator directly before acting on anything here.
MET-233i in other countries
Frequently asked questions
Is MET-233i legal in the United Kingdom?
No. MET-233i is not approved for any medical use in the United Kingdom; its classification is "Investigational, not licensed". Lawful access is limited to registered clinical trials. "Research use only" labeling on vials sold online does not make human use lawful. Human evidence to date: Preliminary.
Can I buy MET-233i in the United Kingdom?
No approved product exists to buy. In the United Kingdom MET-233i is classified as "Investigational, not licensed", so there is no licensed pharmacy product. Vendors selling it "for research use only" are not selling it for human use, and that label does not change its legal status. This site does not list or recommend vendors.
Is MET-233i MHRA approved?
No. In the United Kingdom MET-233i is classified as "Investigational, not licensed", which is not a MHRA marketing approval. For comparison, the US FDA status is: Investigational; Phase 2 (combination). Evidence level: Preliminary.
Related compounds in the United Kingdom
Full research profile
Mechanism, cited studies, FDA status and the full legal summary for MET-233i live on its compound profile.
MET-233i profileThis page is general information about the regulatory status of MET-233i in the United Kingdom, current as of Sep 2026. It is not legal advice, and classifications change; check Medicines and Healthcare products Regulatory Agency directly or consult a lawyer for a specific situation. Educational use only. This database summarizes published research. It is not medical advice and contains no dosing protocols or recommendations for personal use. The Longevity Archive has no vendor relationships and does not recommend where to buy anything.