Legal status · Canada
Is Trigonelline legal in Canada?
Written by Aaron CuhaReviewed Sep 2026
Direct answer
Trigonelline can be sold in Canada as a supplement or cosmetic ingredient. Its legal category is "Sold as a supplement". That is not approval as a drug. Health Canada has not checked any health claim made for it. Versions you inject, and "research use only" versions, fall outside supplement rules, so that label does not make them legal to use in people. On the evidence, no study in people is cited on its profile.
- People given it
- 0
- Found nothing
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Legal category
Sold as a supplement
Health Canada authorisation and DIN status, from the Trigonelline profile.
Reviewed Sep 2026. This is a legal category, not legal advice.
A "research use only" label on a vial does not make it legal to use on people.
Trigonelline in Canada at a glance
| Legal category | Sold as a supplement |
|---|---|
| Health Canada approval status | Not approved by Health Canada as a drug; sold as a supplement or cosmetic |
| Studies in people | 0 of 2 sources on the profile |
| Reviewed | Sep 2026 |
The legal category and note come from the Trigonelline profile. We checked them against Health Canada, Health Products and Food Branch (Health Canada) listings on the reviewed date.
What this means
- 01
Trigonelline can be sold in Canada as a supplement, food or cosmetic ingredient, under the legal category above. It has no approval as a drug.
- 02
Being sold as a supplement means Health Canada has not checked any health claim. The makers are responsible for safety and labels, and quality varies from product to product.
- 03
Versions you inject, and "research use only" versions, are not supplements. That label does not make them legal to use in people, and anything you inject falls under the rules for medicines.
What Trigonelline is
Trigonelline is a natural compound in coffee and fenugreek that the body can turn into NAD+. It improved muscle function in old mice and worms. People with age-related muscle loss have lower levels. No human trial has tested it yet.
A 2024 paper found the body can use trigonelline to make NAD+, a molecule cells need for energy. Blood levels were lower in older adults with age-related muscle loss.
How it works: It feeds the making of NAD+ and supports the energy supply in muscle.
Approval history: Dietary supplement; not a drug
How Health Canada treats this kind of product
Allows a drug to be sold by issuing a Notice of Compliance and a Drug Identification Number (DIN). A compound that is not allowed for sale cannot legally be sold for use in people. Bringing in prescription drugs for your own use is also limited.
The legal category above is how The Longevity Archive reads Health Canada, Health Products and Food Branch listings for Trigonelline on the reviewed date. It is not a legal opinion. Rules change. Bringing a compound into the country, prescribing it and owning it can each be treated differently. Check with the agency before you act on anything here.
Trigonelline in sport and the military
Whether Trigonelline is banned in sport is set by the World Anti-Doping Code and by military rules, not by its legal status in Canada. Before you compete or get tested, look up Trigonelline by name on the Prohibited List, or look up a named product in Global DRO. Under the World Anti-Doping Code, category S0 bans, at all times, any drug-like substance that meets two tests. No other section of the List covers it. And no government health regulator anywhere has a current approval for it as a treatment in people. Many substances that are approved somewhere are banned by name in another section. So approval does not mean a substance is allowed in sport.
- WADA Prohibited List
- Global DRO (check a named product)
- USADA (US athletes)
- Operation Supplement Safety (US service members)
The rules you compete or serve under decide this, not this page.
Trigonelline in other countries
Frequently asked questions
Is Trigonelline legal in Canada?
Trigonelline can be sold in Canada as a supplement or cosmetic ingredient. Its legal category is "Sold as a supplement". That is not approval as a drug. Health Canada has not checked any health claim made for it. Versions you inject, and "research use only" versions, fall outside supplement rules, so that label does not make them legal to use in people. On the evidence, no study in people is cited on its profile.
Can I buy Trigonelline in Canada?
Yes, as a supplement or cosmetic. In Canada, Trigonelline has the legal category "Sold as a supplement". So products you swallow, put on your skin or use as a cosmetic can be sold under supplement rules. Versions you inject, and products labeled "research use only", are not supplements. They are not approved for use in people.
Is Trigonelline Health Canada approved?
No. In Canada, Trigonelline has the legal category "Sold as a supplement". That is not a Health Canada approval to sell it. For comparison, its US FDA status is: Dietary supplement; not a drug. On the evidence, no study in people is cited on its profile.
Related compounds in Canada
Full research profile
How Trigonelline works, the studies we cite, FDA status and the full legal summary are all on its compound profile.
Trigonelline profileThis page is general information about the legal status of Trigonelline in Canada, current as of Sep 2026. It is not legal advice. Legal status changes. For your own situation, check with Health Canada, Health Products and Food Branch or ask a lawyer. Educational use only. This database summarizes published research and is not medical advice. Where a dose appears it is a record of what a trial or clinic ran, or what people describe doing, with its source attached. Nothing here is a recommendation for personal use. Sellers named on the price pages are ranked by certificate tier, then price, and any affiliate income is disclosed there. Naming a seller is not a recommendation to buy or use anything.