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When-X · Coach map · Not a prescription

When homocysteine is high

Homocysteine is the marker the owner's methylated-B rule waits on. B vitamins can lower it. HOPE-2 and NORVIT then showed that lowering it did not deliver the vascular-event benefit people wanted.

Read this first

  • Coach, not doctor. Aaron Cuha is a coach, not a doctor. No medical credential is claimed for him, or for these pages. A number on a blood test is something to talk over with a doctor, not something to diagnose yourself with. Nothing here is a prescription, a plan to follow, or a reason to start or stop a medicine. Educational use only. This database summarizes published research and is not medical advice. Where a dose appears it is a record of what a trial or clinic ran, or what people describe doing, with its source attached. Nothing here is a recommendation for personal use.
  • Knowledge stays free. Knowledge stays free. Every page, every guide and every tool is free to read and stays free. No partner paid for a place on these pages.
  • Three kinds of lab page, kept apart. /bloodwork is blood tests for people. /testing and /prices/labs are lab tests on peptide vials. /supplements/quality is what is in the bottle.

What a coach checks first

Check B12 with MMA, and check folate, before you add folate. Treating folate first can hide B12 deficiency. MTHFR is context, not a protocol.

What this does not mean

It does not mean a methylated B-complex prevents heart attacks or strokes. The large trials moved the number and not the events. It does not mean everyone with an MTHFR variant needs a bottle.

Markers to ask for on the blood test order

Supplements worth asking about, not orders

What people typically order

Ask for homocysteine, serum B12, MMA, and folate. A clinician decides whether MTHFR testing adds anything. Do not start high-dose folate alone.

Bloodwork partners · Supplement brand partners

When to stop

If you and a clinician trial B vitamins, retest homocysteine at about ninety days. If it did not move, stop. If it moved, remember that the outcome trials still failed. Do not take movement as a saved life.