Head to head
Fisetin against Dasatinib
A supplement and a leukaemia drug, used for the same purpose by different groups of people. Dasatinib is prescription only and is usually combined with quercetin; the open-label pilots were promising and the randomised trials that followed were not.
Column A
FisetinFisetin (senolytic flavonoid)
A plant flavonoid and leading natural senolytic. One mouse study reported extended lifespan; the multi-site programme built to replicate such results found no effect.
Column B
DasatinibDasatinib (senolytic; approved leukemia drug)
An FDA-approved leukemia drug repurposed as a senolytic with quercetin. The open-label pilots were promising; the randomised trials that followed were not.
Side by side, on the facts we can check
| Attribute | Fisetin | Dasatinib |
|---|---|---|
| Category | Longevity | Longevity |
| FDA status | Sold as a supplement; in clinical trials for aging | FDA-approved for leukemia; senolytic use is off-label and investigational |
| Half-life | ~1-3 hours | ~3-5 hours |
| Molecular weight | 286.2 Da | 488.0 Da |
| Mechanism | Selectively triggers death of senescent cells, reducing the inflammatory signals they release. | Inhibits survival signaling in senescent cells, triggering their death, especially alongside quercetin. |
| Human studies cited | 1 | 4 |
| Legal status, US | Sold as a dietary supplement | FDA-approved (for its labeled use), prescription only |
Frequently asked questions
What is the difference between Fisetin and Dasatinib?
Fisetin: A plant flavonoid and leading natural senolytic. One mouse study reported extended lifespan; the multi-site programme built to replicate such results found no effect. Dasatinib: An FDA-approved leukemia drug repurposed as a senolytic with quercetin. The open-label pilots were promising; the randomised trials that followed were not.
Which has stronger research evidence, Fisetin or Dasatinib?
This database does not grade compounds. It counts what was run in people: 1 of the 3 studies cited on the Fisetin profile were human work, against 4 of 6 for Dasatinib. Those counts are of our own citation lists and understate any larger literature, and neither is a recommendation.
Are Fisetin and Dasatinib FDA-approved?
Fisetin: Sold as a supplement; in clinical trials for aging. Dasatinib: FDA-approved for leukemia; senolytic use is off-label and investigational.
Related posts
Blog articles that cover Fisetin or Dasatinib, newest first.
- Longevity / Sep 8, 2026 / 12 minPeptides for Longevity: What the Evidence Actually Shows in 2026
- Longevity / Sep 8, 2026 / 9 minSenolytics in 2026: Dasatinib plus Quercetin, Fisetin, and What Human Trials Have Shown
- Longevity / Sep 8, 2026 / 9 minThe Rapamycin Dosing Debate: What PEARL Tested, the Bioavailability Problem, and What Is Unproven
- Longevity / Sep 8, 2026 / 8 minKlotho Explained: Protein, Peptide, Gene Therapy or Supplement?
Reviewed Sep 2026. This page sets two published records side by side. It is educational, it is not medical advice, and it contains no dosing protocols or recommendations for personal use.