Peptide finder

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Pick as many as you like. The number on each one is how many people it has been measured in across the whole archive. So you can see where the evidence is before you choose.

1. 01NRPTSupplementModerate. At least one finished study in people, and at least 100 people who took it. 3 completed trials, 176 people given it.3 reported

   144 people2 studies1 found nothing

   • The pills raise NAD in the blood, and that is all this trial measured. 120 healthy adults aged 60 to 80 took a dummy pill, the recommended dose, or double, every day for eight weeks, and nobody involved knew which. NAD rose about 40 percent on the normal dose and about 90 percent on the double, and stayed up for the...

     npj Aging and Mechanisms of Disease, 2017 · 120 people

   • found nothingThe pills raised NAD in patients with sudden kidney injury, and nothing about their kidneys changed. 24 hospital patients took rising doses of the combination or a dummy for two days. The kidney injury itself halved NAD in the untreated patients, which is a finding in its own right. Pooled across doses the supplement...

     BMC Nephrology, 2020 · 24 people

2. 02NMNSupplementLimited. People have taken it in a published study, but fewer than 100 of them. 4 completed trials, 94 people given it.6 reported

   80 people1 study1 found nothing

   • found nothingNMN raised NAD in the blood and added a little to how far people could walk, and did nothing for blood sugar handling. Eighty healthy middle aged adults took one of three daily doses or a dummy for two months, and nobody involved knew which. Walking distance in six minutes improved modestly. Insulin resistance did not...

     GeroScience, 2023 · 80 people

3. 03MIB-626SupplementModerate. At least one finished study in people, and at least 100 people who took it. 4 completed trials, 107 people given it.1 reported

   42 people2 studies1 found nothing

   • found nothingThe tablet raised NAD in very sick patients and made no difference to them. 42 adults in hospital with COVID-19 and sudden kidney injury took MIB-626 or dummy tablets twice a day for two weeks. NAD in the blood roughly doubled by the end. Kidney blood tests came out the same in both groups. So did inflammation markers...

     FASEB BioAdvances, 2025 · 42 people

   • This trial shows the tablet raises NAD in the blood, and nothing beyond that. 32 overweight or obese adults aged 55 to 80 took MIB-626 once a day, twice a day, or a dummy tablet for two weeks, and nobody involved knew which. NMN in the blood was clearly higher by the end, and NAD rose more on the bigger dose. Sex,...

     Journals of Gerontology Series A, 2023 · number of people not given

4. 04NAD+ / B ComplexBlendLimited. People have taken it in a published study, but fewer than 100 of them. 5 completed trials, 34 people given it.8 reported

   34 people2 studies

   • The vitamin drip did not beat salt water. Thirty four adults with fibromyalgia were given either the vitamin mixture or a plain fluid drip every week for two months. Both groups felt better. Neither group felt better than the other, at two months or at four. Sitting for an hour with a needle in your arm does something...

     Journal of Alternative and Complementary Medicine, 2009 · 34 people

   • The first look at NAD+ given by drip in people, and it measured chemistry rather than benefit. Blood was sampled through a six hour infusion. Nothing rose in the blood for the first two hours, which suggests the body takes it up or breaks it down quickly. Nobody was tested for energy, thinking, sleep or anything else...

     Frontiers in Aging Neuroscience, 2019 · number of people not given

5. 05ResveratrolSupplementModerate. At least one finished study in people, and at least 100 people who took it. 14 completed trials, 403 people given it.7 reported

   11 people3 studies2 found nothing

   • This is the strongest good human result resveratrol has, and it rests on eleven men. Obese but otherwise healthy men took 150 mg a day for a month, and also spent a month on a dummy pill. Their resting metabolism slowed the way it does when people eat less. Liver fat, blood sugar, triglycerides, a liver enzyme and...

     Cell Metabolism, 2011 · 11 people

   • found nothingRun again at a high dose, the same idea produced nothing. Twenty-four obese but otherwise healthy men took high-dose resveratrol or a dummy pill for four weeks. The main measure was how well their bodies answered insulin, using the most exacting test there is. It drifted slightly worse in both groups. Blood pressure,...

     Diabetes, 2013 · number of people not given

   • found nothingResveratrol did nothing in healthy postmenopausal women, right down to the mechanism. They took 75 mg daily for 12 weeks, and blood tests confirm it reached them. The most exacting test of insulin response found no change in liver, muscle or fat. Body composition, resting metabolism, blood fats and inflammation...

     Cell Metabolism, 2012 · number of people not given

6. 06EpicatechinSupplementLimited. People have taken it in a published study, but fewer than 100 of them. 4 completed trials, 44 people given it.1 reported

   7 people1 study

   • In a muscle-wasting disease, epicatechin moved the biology, but nobody went without it. Seven adults with Becker muscular dystrophy who could still walk took 50 mg twice a day for eight weeks, with a muscle sample taken before and after. Markers of mitochondrial building and muscle repair rose, myostatin fell, and...

     Muscle and Nerve, 2021 · 7 people

7. 07Nicotinamide RibosideSupplementLimited. People have taken it in a published study, but fewer than 100 of them. 4 completed trials, 90 people given it.5 reported

   number of people not given4 studies1 found nothing

   • Swallowing this form of vitamin B3 really does raise NAD in the blood. In a small human study the level rose by up to nearly three times. That single fact is what the entire NAD supplement industry is built on. Raising a level in the blood is the start of an argument, not the end of it. Nobody in this study got...

     Nature Communications, 2016 · number of people not given

   • Six weeks of it was comfortable to take, and it lifted NAD as expected. Adults in middle age and older each did a stretch on the supplement and a stretch without it. What was measured was body chemistry. No symptom, no performance test and no disease outcome was looked at here.

     Nature Communications, 2018 · number of people not given

   • Eight weeks of it was safe in healthy overweight adults, and larger doses raised NAD further. Some people got the supplement and some got a dummy pill. The study was built to check safety and find a dose, and that is what it answered. It was not built to show a benefit, and it did not show one.

     Scientific Reports, 2019 · number of people not given

8. 08NAD+SupplementLimited. People have taken it in a published study, but fewer than 100 of them. 1 completed trial, none stating how many people.7 reported

   number of people not given1 study

   • The first time anyone measured what a NAD drip actually does in people, and it measured nothing about whether it helps. Blood was sampled during a six hour infusion. For the first two hours, NAD in the blood did not go up, nor did its breakdown products. The likely explanation is that tissues take it up or destroy it...

     Frontiers in Aging Neuroscience, 2019 · number of people not given

9. 09Metformin plus rapamycinSmall moleculePreliminary. Studied in people, but no published study has had people take it. 2 registered with no result.2 reported

   number of people not given1 study

   • The one trial testing this pair cannot tell the two drugs apart. 30 people are enrolled by AgelessRx, an online company that prescribes these drugs, and it is no longer signing people up. Every group stacks rapamycin and metformin together with low-dose naltrexone, NAD+ up the nose, glutathione on the skin and a...

     ClinicalTrials.gov, 2025 · number of people not given

10. 10NMNHSupplementLimited. People have taken it in a published study, but fewer than 100 of them. 1 completed trial, none stating how many people.1 reported

    number of people not given1 study

    • This is the human trial the reduced form does not have. 32 overweight or obese adults aged 55 to 80 took an oral NMN tablet once or twice a day for two weeks, or a dummy tablet, and nobody involved knew which. NMN in the blood ended clearly above the dummy group, and NAD rose more on the bigger dose. Those are blood...

      Journals of Gerontology Series A, 2023 · number of people not given

11. 11CotadutidePeptideStrong. At least two finished studies in people, and at least 1,000 people who took it. 6 completed trials, 1,221 people given it.

    number of people not given1 study1 found nothing

    • found nothingPeople lost weight on cotadutide because they ate less, not because they burned more. This small study followed 12 people on the drug and 7 on a dummy for six weeks. The drug group lost four percent of their body weight against one and a half percent on the dummy. They ate far less food. Energy burned, measured...

      Diabetes, Obesity and Metabolism, 2024 · number of people not given

12. 12Peptide YYPeptideLimited. People have taken it in a published study, but fewer than 100 of them. 3 completed trials, 12 people given it.3 reported

    number of people not given1 study1 found nothing

    • found nothingCopying the hormone mix that follows stomach bypass surgery cut food intake by about a third. Obese volunteers wore a pump under the skin for about ten and a half hours, delivering three gut hormones at post-surgery levels, or a dummy infusion. Each person tried both, in turn, and did not know which was running. They...

      Journal of Clinical Endocrinology and Metabolism, 2017 · number of people not given

13. 13OxyntomodulinPeptideLimited. People have taken it in a published study, but fewer than 100 of them. 1 completed trial, 13 people given it.

    number of people not given1 study

    • People ate less, and they did not burn more. 15 healthy young men got oxyntomodulin, GLP-1, glucagon, the last two together, or salt water before a meal, on separate days. Every hormone cut how much they ate, by about the same amount. Giving GLP-1 and glucagon together added nothing. Oxygen use, which is how energy...

      Journal of Clinical Endocrinology and Metabolism, 2015 · number of people not given

14. 14NAD+ with glutathioneBlendLimited. People have taken it in a published study, but fewer than 100 of them. 1 completed trial, 21 people given it.5 reported

    number of people not given1 study

    • Swallowing nicotinamide riboside does raise NAD in the blood, and that is all this study set out to show. Healthy volunteers took it, everyone knew they were taking it, and there was no comparison group. Blood NAD roughly doubled, and the rise matched how much of the compound got into the blood. No side effects were...

      PLoS One, 2017 · number of people not given

15. 15RilmenidineSmall moleculePreliminary. Studied in people, but no published study has had people take it. 1 human study where nobody was given it.1 reported

    number of people not given0 studies

    • In worms. Rilmenidine made tiny worms live longer and handle stress better, whether they started young or old. It only worked through one specific receptor and the cell's clean-up system. It added nothing for worms already eating less or on rapamycin. In mice, it changed genes in the liver and kidney to look like...

      Aging Cell, 2023 · number of people not given

    • In mice. In mice bred to get a muscle-wasting nerve disease, rilmenidine switched on cell clean-up in the spinal cord as planned. The harmful protein went down. But the nerve cells died faster and the mice got sicker faster. The authors blame too much clearing of the power plants inside nerve cells.

      Autophagy, 2018 · number of people not given

16. 16AdiponectinBiologicPreliminary. Studied in people, but no published study has had people take it. 3 human studies where nobody was given it.2 reported

    number of people not given0 studies

    • In mouse cells and tissues. This paper found adiponectin's two receptors, AdipoR1 and AdipoR2. It showed they carry adiponectin's effects on fat burning and sugar uptake.

      Nature, 2003 · number of people not given

    • In mice. AdipoRon, a pill-type molecule, switched on both adiponectin receptors. It helped insulin work and improved blood sugar handling in mice on a high-fat diet. It did nothing in mice missing both receptors. It eased diabetes in a diabetic strain and lengthened their shortened lifespan. Mouse only. There is no...

      Nature, 2013 · number of people not given

17. 17SpermidineSupplementModerate. At least one finished study in people, and at least 100 people who took it. 2 completed trials, 130 people given it.4 reported

    number of people not given0 studies

    • In mice, spermidine given by mouth made them live longer and kept their hearts working better. It did this by boosting clean-up inside heart cells.

      Nature Medicine, 2016 · number of people not given

18. 18Ginsenoside Rg3SupplementLimited. People have taken it in a published study, but fewer than 100 of them. 1 completed trial, 24 people given it.

    number of people not given0 studies

    • In a dish. The 20(S) form brought worn-out human skin cells back to a younger state by restoring their energy supply and changing growth and repair signals. The 20(R) form did not. This is bringing worn-out cells back, not clearing them.

      Journal of Ginseng Research, 2020 · number of people not given

19. 19HalofuginoneSmall moleculePreliminary. Studied in people, but no published study has had people take it. 3 human studies where nobody was given it, 1 registered with no result.2 reported

    number of people not given0 studies

    • In obese mice and in pigs. Halofuginone cut how much the animals ate, raised the energy they burned, and caused weight loss. It worked by raising two hormones, FGF21 and GDF15. Mice bred without those hormones did not respond. Note that the paper calls halofuginone FDA-approved for scleroderma. The FDA's approved drug...

      Science Advances, 2025 · number of people not given

20. 20Alpha-ketobutyrateSupplementPreliminary. Studied in people, but no published study has had people take it. 2 human studies where nobody was given it.3 reported

    number of people not given0 studies

    • In worms. Adding alpha-ketobutyrate made normal worms live longer. It worked through a long chain: more NAD+, the worm's sirtuin gene, more active peroxisomes that burn fats, hydrogen peroxide as a signal, and finally the worm's version of NRF2 turning on cleanup genes. In a dish, skin cells also aged more slowly....

      Nature Communications, 2023 · number of people not given

21. 21ApigeninSupplementPreliminary. Studied in people, but no published study has had people take it. 1 human study where nobody was given it.1 reported

    number of people not given0 studies

    • In mice. This is the strongest evidence for blocking CD38, and it did not use apigenin. A strong, precise blocker called 78c reversed the fall in NAD with age. It improved blood sugar control, muscle function, exercise ability and heart function, in mice that aged normally or fast. An author holds a patent on CD38...

      Cell Metabolism, 2018 · number of people not given

22. 22CartalaxPeptideAnimal or lab only. Only animal or lab studies on this page. No study in people yet. 4 lab studies, no human study.8 reported

    number of people not given0 studies

    • In a dish. Aging cartilage cells gave off more aging and inflammation signals. Both Cartalax and a cartilage extract pushed those signals back toward normal. These were cells, not joints, and nobody measured a real health result.

      Advances in Gerontology, 2023 · number of people not given

23. 23SS-20PeptideAnimal or lab only. Only animal or lab studies on this page. No study in people yet. 4 animal studies, 1 lab study, no human study.6 reported

    number of people not given0 studies

    • In mice. Mice were given a toxin that mimics Parkinson's disease. SS-31 fully protected their dopamine brain cells at higher doses. SS-20, which cannot mop up free radicals, also gave real protection. Both kept mitochondria working in lab tests.

      Antioxidants and Redox Signaling, 2009 · number of people not given

24. 245-amino-1MQ with SLU-PP-332BlendAnimal or lab only. Only animal or lab studies on this page. No study in people yet. 2 animal studies, no human study.7 reported

    number of people not given0 studies

    • In a dish and in mice, this type of molecule blocked the NNMT enzyme cleanly and got into cells easily. In fat cells in a dish, it raised NAD+ inside the cells. In mice made fat on a high fat diet, a strong version reversed the weight gain. This was cells and mice. No person was given it.

      Biochemical Pharmacology, 2018 · number of people not given