Which is stronger, semaglutide, tirzepatide, or retatrutide?

Judged purely by average weight loss percentage across their separate trials, retatrutide's Phase 3 result, up to 28.3% at 80 weeks, is larger than tirzepatide's, up to 21% at 72 weeks, which is larger than semaglutide's approved dose result, around 15%. These numbers come from three separate trials in different populations, not one study comparing all three head to head, and retatrutide remains investigational, not an approved drug like the other two.

Educational use only. This database summarizes published research and is not medical advice. Where a dose appears it is a record of what a trial or clinic ran, or what people describe doing, with its source attached. Nothing here is a recommendation for personal use.

Part of combining and comparing peptides. Stacks, head-to-head comparisons, and what happens when nobody has tested the combination.