Which is stronger, semaglutide, tirzepatide, or retatrutide?

Going only by average weight loss in their separate studies, retatrutide's result in its large final-stage study, up to 28.3% at 80 weeks, is bigger than tirzepatide's, up to 21% at 72 weeks. That is bigger than the result for semaglutide's approved dose, around 15%. But these numbers come from three separate studies in different groups of people, not one study comparing all three. And retatrutide is still experimental, not an approved drug like the other two.

Educational use only. This database summarizes published research and is not medical advice. Where a dose appears it is a record of what a trial or clinic ran, or what people describe doing, with its source attached. Nothing here is a recommendation for personal use.

Part of combining and comparing peptides. Stacks, head-to-head comparisons, and what happens when nobody has tested the combination.