Peptide finder

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Pick as many as you like. The number on each one is how many people it has been measured in across the whole archive. So you can see where the evidence is before you choose.

1. 01MOTS-cPeptideLimited. People have taken it in a published study, but fewer than 100 of them. 1 completed trial, 30 people given it.6 reported

   30 people2 studies1 found nothing

   • Exercise did not move MOTS-c. Thirty adults were assigned to a bout of endurance exercise, a bout of weight training, or nothing at all. Humanin, a related peptide, rose after the endurance session and not after the weights. MOTS-c leaned upward but not enough to call it a real change. Neither peptide tracked how fit...

     Journal of Applied Physiology, 2021 · 30 people

   • found nothingProfessional athletes carried less MOTS-c in their blood than people who do not train, which is the opposite of what a fitness marker should do. Seventy-five athletes were compared with thirty sedentary adults. Nobody was given anything. Humanin, the related peptide, went the other way and was higher in the athletes....

     Reviews in Cardiovascular Medicine, 2022 · number of people not given

2. 02HumaninPeptideLimited. People have taken it in a published study, but fewer than 100 of them. 1 completed trial, 30 people given it.6 reported

   30 people2 studies

   • A single endurance session raises humanin in the blood. Lifting weights does not. Thirty adults were assigned to one bout of endurance exercise, one bout of weight training, or nothing. Humanin went up only after the endurance session. It did not track how fit anyone was, measured by running capacity, by strength, or...

     Journal of Applied Physiology, 2021 · 30 people

   • Athletes carried more humanin than people who do not train, but more training did not mean more humanin. Seventy-five professional athletes were compared with thirty sedentary adults. Nobody was given anything. The athletes had higher levels overall. Inside the athlete group the pattern reversed, because the hardest...

     Reviews in Cardiovascular Medicine, 2022 · number of people not given

3. 03PQQSupplementModerate. At least one finished study in people, and at least 100 people who took it. 3 completed trials, 116 people given it.5 reported

   23 people1 study1 found nothing

   • found nothingPQQ added nothing on top of training. 23 untrained men took 20 mg a day or a dummy while doing the same supervised six week endurance programme. Both groups got fitter, from the training. Neither peak oxygen uptake nor how long they lasted separated the two groups. One protein linked to building new mitochondria rose...

     Journal of the American College of Nutrition, 2020 · 23 people

4. 04ClenbuterolSmall moleculeLimited. People have taken it in a published study, but fewer than 100 of them. 2 completed trials, 11 people given it.5 reported

   11 people1 study1 found nothing

   • found nothingClenbuterol does build muscle in people, and it wrecks your fitness while it does. 11 healthy young men took the drug for two weeks and a dummy for two weeks, in turn, with three weeks between. Lean mass rose by just under a kilogram. Fat mass did not move at all, which matters because fat loss is why most people buy...

     The Journal of Physiology, 2025 · 11 people

5. 05EpitalonPeptideModerate. At least one finished study in people, and at least 100 people who took it. 5 completed trials, 266 people given it.6 reported

   number of people not given1 study

   • The same small group of Kiev heart patients, followed for much longer. 39 heart patients took six courses of epithalamin over three years alongside their usual treatment. 40 others had usual treatment only. The treated group was reported to age more slowly in the heart and blood vessels, keep more stamina, recover a...

     Bulletin of Experimental Biology and Medicine, 2011 · number of people not given

6. 06NMNSupplementLimited. People have taken it in a published study, but fewer than 100 of them. 4 completed trials, 94 people given it.6 reported

   number of people not given1 study1 found nothing

   • found nothingA high dose NMN tablet raised NAD in the blood and moved weight and cholesterol, but not muscle. 30 overweight or obese adults took MIB-626, 1000 mg twice a day, or a dummy pill, for 28 days. Weight fell 1.9 kg. The lower blood pressure number and LDL cholesterol fell too. Strength, tiredness, fitness and stair...

     Journal of Clinical Endocrinology and Metabolism, 2023 · number of people not given

7. 07VIPPeptideLimited. People have taken it in a published study, but fewer than 100 of them. 1 completed trial, none stating how many people.2 reported

   number of people not given1 study

   • A small, early study in a serious lung condition, with everyone knowing what they were getting. People with high blood pressure in the lungs breathed in VIP. Pressures in the lung circuit improved and they could walk further. All of them were short of VIP to begin with, which is the best case there is for giving it...

     Journal of Clinical Investigation, 2003 · number of people not given

8. 08Urolithin ASupplementLimited. People have taken it in a published study, but fewer than 100 of them. 2 completed trials, none stating how many people.4 reported

   number of people not given2 studies1 found nothing

   • found nothingFour months of it improved muscle endurance and blood chemistry, and left the headline measures untouched. Older adults took the supplement or a dummy. How far they could walk in six minutes did not differ, and neither did the peak energy their muscles could produce. What improved was how long a muscle could keep...

     JAMA Network Open, 2022 · number of people not given

   • Strength improved, and the trial still missed the thing it was built to show. Muscle strength in middle-aged adults rose about 12 percent, and fitness and walking distance improved as well. But peak power, the one measure chosen before the trial began, did not. When a study misses the measure it named first and hits...

     Cell Reports Medicine, 2022 · number of people not given

9. 09(R/S)-1,3-ButanediolSupplementLimited. People have taken it in a published study, but fewer than 100 of them. 1 completed trial, none stating how many people.2 reported

   number of people not given1 study

   • It raised ketones in the blood, made people feel ill, and did not make them faster. Nine trained male cyclists took either 1,3-butanediol or a dummy drink before and during 85 minutes of steady riding, then a time trial. Each rider did both, in turn. Blood ketones rose several times over, so the compound does what it...

     International Journal of Sport Nutrition and Exercise Metabolism, 2019 · number of people not given

10. 10Metformin plus rapamycinSmall moleculePreliminary. Studied in people, but no published study has had people take it. 2 registered with no result.2 reported

    number of people not given1 study

    • The one trial testing this pair cannot tell the two drugs apart. 30 people are enrolled by AgelessRx, an online company that prescribes these drugs, and it is no longer signing people up. Every group stacks rapamycin and metformin together with low-dose naltrexone, NAD+ up the nose, glutathione on the skin and a...

      ClinicalTrials.gov, 2025 · number of people not given

11. 11MIB-626SupplementModerate. At least one finished study in people, and at least 100 people who took it. 4 completed trials, 107 people given it.1 reported

    number of people not given1 study1 found nothing

    • found nothingThe tablet moved some body measurements and left every measure of physical function untouched. 30 overweight or obese adults aged 45 and over took MIB-626 or a dummy tablet for four weeks. Weight fell by about two kilograms. Blood pressure and cholesterol both came down. Strength, stamina, how quickly muscles tired...

      Journal of Clinical Endocrinology and Metabolism, 2023 · number of people not given

12. 12Urolithin BSupplementLimited. People have taken it in a published study, but fewer than 100 of them. 1 completed trial, none stating how many people.

    number of people not given1 study1 found nothing

    • found nothingThis is urolithin A, not urolithin B, and it sits here because urolithin B has nothing like it. Older adults took urolithin A or a dummy. Muscle endurance improved and some blood markers moved. The six minute walk test did not improve, and neither did the peak energy output measured inside muscle. So even the better...

      JAMA Network Open, 2022 · number of people not given

13. 13SLU-PP-332Small moleculeAnimal or lab only. Only animal or lab studies on this page. No study in people yet. 2 animal studies, no human study.8 reported

    number of people not given0 studies

    • In mice: SLU-PP-332 switched on the same muscle genes that aerobic exercise turns on, and the mice could run longer.

      ACS Chemical Biology, 2023 · number of people not given

14. 14CardarineSmall moleculePreliminary. Studied in people, but no published study has had people take it. 1 registered with no result.7 reported

    number of people not given0 studies

    • In mice. With training, it improved endurance.

      Cell, 2008 · number of people not given

15. 15GW0742Small moleculeAnimal or lab only. Only animal or lab studies on this page. No study in people yet. 3 animal studies, 1 lab study, no human study.3 reported

    number of people not given0 studies

    • In mice trained on a treadmill for four weeks. AICAR alone boosted endurance. AICAR plus GW0742 raised running time by 138 to 179 percent against trained mice. The mice burned more fat and saved their sugar stores. This is mice, with a drug pair, not GW0742 alone in a person.

      Physiological Reports, 2016 · number of people not given

16. 165-amino-1MQ with SLU-PP-332BlendAnimal or lab only. Only animal or lab studies on this page. No study in people yet. 2 animal studies, no human study.7 reported

    number of people not given0 studies

    • In muscle cells in a dish, SLU-PP-332 made the cells' energy makers work harder. In mice, it raised the number of endurance-type muscle fibres, let the mice run longer, and switched on the same genes that aerobic exercise does. This was cells and mice. There is no data in people.

      ACS Chemical Biology, 2023 · number of people not given

17. 17VilonPeptideAnimal or lab only. Only animal or lab studies on this page. No study in people yet. 1 animal study, 1 lab study, no human study.6 reported

    number of people not given0 studies

    • In mice. Vilon given from 6 months of age made female mice more active, gave them more stamina, helped them live longer and cut tumors.

      Bulletin of Experimental Biology and Medicine, 2000 · number of people not given

18. 18AICARSmall moleculeModerate. At least one finished study in people, and at least 100 people who took it. 1 completed trial, 3,080 people given it.5 reported

    number of people not given0 studies

    • In mice. It raised endurance in mice that did not train by about 44%.

      Cell, 2008 · number of people not given

19. 19Rapamycin plus acarboseSmall moleculeAnimal or lab only. Only animal or lab studies on this page. No study in people yet. 7 animal studies, no human study.5 reported

    number of people not given0 studies

    • In mice. Each drug alone, started at 4 or 16 months, helped old mice of both sexes balance on a spinning rod and keep going longer, and shrank their enlarged hearts. Acarbose changed the fats in the heart more than rapamycin. Some benefits showed up in males only. These are health measures for each drug alone, not for...

      Journals of Gerontology Series A, 2023 · number of people not given

20. 20ApigeninSupplementPreliminary. Studied in people, but no published study has had people take it. 1 human study where nobody was given it.1 reported

    number of people not given0 studies

    • In mice. This is the strongest evidence for blocking CD38, and it did not use apigenin. A strong, precise blocker called 78c reversed the fall in NAD with age. It improved blood sugar control, muscle function, exercise ability and heart function, in mice that aged normally or fast. An author holds a patent on CD38...

      Cell Metabolism, 2018 · number of people not given

21. 21Senolytic CAR T cellsBiologicAnimal or lab only. Only animal or lab studies on this page. No study in people yet. 3 animal studies, no human study.

    number of people not given0 studies

    • In mice. A single dose of the uPAR-hunting T cells helped normally ageing mice exercise more. It helped old mice and mice on a high-fat diet handle blood sugar better. The effect lasted, and it also worked as prevention.

      Nature Aging, 2024 · number of people not given

22. 22IrisinBiologicLimited. People have taken it in a published study, but fewer than 100 of them. 1 completed trial, 7 people given it.2 reported

    number of people not given0 studies

    • found nothingMostly in a dish, plus muscle samples from people. The human irisin gene has a broken start signal. With that signal, cells in a dish made only about 1 percent of the normal protein. In muscle samples from two human exercise studies, the gene did not get more active after cardio or weight training. In a dish, irisin...

      PLoS One, 2013 · number of people not given

23. 23EnobosarmSmall moleculeModerate. At least one finished study in people, and at least 100 people who took it. 1 completed trial, 159 people given it.5 reported

    number of people not given0 studies
24. 24SR9009Small moleculeAnimal or lab only. Only animal or lab studies on this page. No study in people yet. 1 animal study, 1 lab study, no human study.4 reported

    number of people not given0 studies