Peptide finder

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Pick as many as you like. The number on each one is how many people it has been measured in across the whole archive. So you can see where the evidence is before you choose.

1. 01MelittinPeptideModerate. At least one finished study in people, and at least 100 people who took it. 5 completed trials, 658 people given it.4 reported

   538 people1 study

   • This tested whole bee venom, not melittin. Five hundred and thirty eight people with knee arthritis got weekly skin injections of venom, or of a control substance, for twelve weeks. Pain and physical function improved more on the venom. The gains were modest in size. Reactions where the needle went in were uncommon....

     Journal of Alternative and Complementary Medicine, 2019 · 538 people

2. 02MethotrexateSmall moleculeStrong. At least two finished studies in people, and at least 1,000 people who took it. 2 completed trials, 5,022 people given it.4 reported

   236 people1 study

   • A year of methotrexate given before rheumatoid arthritis was diagnosed did not stop the arthritis from arriving. 236 adults with joint pain took part. They also got one steroid shot at the start. They did have less pain, stiffness and joint inflammation two years on. One region, and an early test of the idea.

     The Lancet, 2022 · 236 people

3. 03UBX0101Small moleculeModerate. At least one finished study in people, and at least 100 people who took it. 1 completed trial, 183 people given it.3 reported

   183 people1 study

   • The first clean-up drug ever tested against a real symptom in people failed. 183 people with knee arthritis got one shot of UBX0101 at one of three strengths, or a dummy shot. After 12 weeks, knee pain had fallen from about 2.1 to 1.12 on the dummy shot and to between 1.04 and 1.16 on the drug. Knee function and daily...

     ClinicalTrials.gov, 2026 · 183 people

4. 04CurcuminSupplementModerate. At least one finished study in people, and at least 100 people who took it. 3 completed trials, 195 people given it.5 reported

   95 people2 studies

   • A high-absorption curcumin form eased knee pain in a short study. 50 adults with knee arthritis took 180 mg a day, or a dummy pill, for 8 weeks. Pain scores were lower on the curcumin form, except in people who started with almost no pain. They also needed less of the pain drug celecoxib. Eight weeks is short, and...

     Journal of Orthopaedic Science, 2014 · 50 people

   • A very small rheumatoid arthritis pilot put 45 people on curcumin, a pain drug (diclofenac), or both. Disease scores improved in all three groups, and the curcumin-only group improved most. 45 people split three ways cannot settle a long-term disease. Treat it as a reason to run a proper study, not as proof.

     Phytotherapy Research, 2012 · 45 people

5. 05Alpha-2-MacroglobulinBiologicLimited. People have taken it in a published study, but fewer than 100 of them. 1 completed trial, 75 people given it.6 reported

   75 people1 study1 found nothing

   • found nothingA2M injections helped knees, but no better than the cheaper options they were tested against. 75 people with moderate knee osteoarthritis were split by chance between an A2M-rich concentrate, ordinary platelet-rich plasma, and a steroid injection. Nobody involved knew which. 68 finished. At 12 weeks the A2M group had...

     Bulletin of the Hospital for Joint Diseases, 2024 · 75 people

6. 06PiperlongumineSmall moleculeAnimal or lab only. Only animal or lab studies on this page. No study in people yet. 1 animal study, 3 lab studies, no human study.2 reported

   number of people not given0 studies

   • In rats. Piperlongumine cut signs of worn-out cells in knee tissue and slowed knee arthritis. The researchers also tested cells taken from people with arthritis, but only in a dish. No patients were treated.

     Biochemical and Biophysical Research Communications, 2026 · number of people not given

7. 07CartalaxPeptideAnimal or lab only. Only animal or lab studies on this page. No study in people yet. 4 lab studies, no human study.8 reported

   number of people not given0 studies

   • In a dish. Aging cartilage cells gave off more aging and inflammation signals. Both Cartalax and a cartilage extract pushed those signals back toward normal. These were cells, not joints, and nobody measured a real health result.

     Advances in Gerontology, 2023 · number of people not given

8. 08Nandrolone decanoateHormoneLimited. People have taken it in a published study, but fewer than 100 of them. 3 completed trials, none stating how many people.6 reported

   number of people not given0 studies
9. 09BPC-157PeptideLimited. People have taken it in a published study, but fewer than 100 of them. 3 completed trials, 31 people given it.10 reported

   number of people not given0 studies
10. 10RapamycinSmall moleculeLimited. People have taken it in a published study, but fewer than 100 of them. 2 completed trials, 25 people given it.8 reported

    number of people not given0 studies
11. 11GLOW blendBlendLimited. People have taken it in a published study, but fewer than 100 of them. 2 completed trials, 22 people given it.9 reported

    number of people not given0 studies
12. 12Rapamycin plus acarboseSmall moleculeAnimal or lab only. Only animal or lab studies on this page. No study in people yet. 7 animal studies, no human study.5 reported

    number of people not given0 studies
13. 13Testosterone cypionateHormoneModerate. At least one finished study in people, and at least 100 people who took it. 1 completed trial, 5,246 people given it.9 reported

    number of people not given0 studies
14. 14Deadpool blendBlendAnimal or lab only. Only animal or lab studies on this page. No study in people yet. 1 animal study, 1 lab study, no human study.7 reported

    number of people not given0 studies
15. 15PDA with TB-500BlendAnimal or lab only. Only animal or lab studies on this page. No study in people yet. 1 lab study, no human study.6 reported

    number of people not given0 studies
16. 16Semaglutide with BPC-157BlendLimited. People have taken it in a published study, but fewer than 100 of them. 1 completed trial, none stating how many people.7 reported

    number of people not given0 studies

1. 01Zoledronic acidSmall moleculeStrong. At least two finished studies in people, and at least 1,000 people who took it. 4 completed trials, 7,176 people given it.

   5,065 people3 studies

   • The bone drip prevented broken bones in older women with thinning bones. Two thousand New Zealand women aged 65 and over got four infusions of either the drug or plain salt water over six years, spaced eighteen months apart. Fragility fractures happened in 122 women on the drug and 190 on salt water. Roughly fifteen...

     New England Journal of Medicine, 2018 · 2,000 people

   • Fewer heart attacks, cancers and deaths turned up on the bone drip, but this was a side look, not the question the trial asked. It re-counted the illnesses and harms recorded in the same two thousand women. Heart attacks fell from 39 women to 24. Cancers fell by about a third. Deaths leaned lower without being clearly...

     Journal of Bone and Mineral Research, 2020 · 2,000 people

   • A once a year bone drip after a broken hip cut later fractures, and fewer people died. Around two thousand people, average age in their mid seventies, got the drip or a dummy one within three months of hip surgery, then were followed about two years. New fractures hit about 9 in every hundred on the drug and about 14...

     New England Journal of Medicine, 2007 · 1,065 people

2. 02PioglitazoneSmall moleculeStrong. At least two finished studies in people, and at least 1,000 people who took it. 2 completed trials, 9,114 people given it.5 reported

   3,876 people1 study

   • In people with insulin resistance but no diabetes who had just had a stroke or a mini-stroke, pioglitazone lowered the chance of another stroke or a heart attack over about five years. It also halved new diabetes. It cost more weight gain, swelling and broken bones. Death rates were about the same.

     The New England Journal of Medicine, 2016 · 3,876 people

3. 03DHEAHormoneModerate. At least one finished study in people, and at least 100 people who took it. 3 completed trials, 267 people given it.5 reported

   243 people2 studies1 found nothing

   • found nothingThe biggest study of DHEA against a dummy pill as an anti-ageing supplement found nothing that mattered. 144 older men and women with low levels took it for two years. The hormone went up and little else changed. Body shape, strength, fitness, blood sugar control and quality of life did not get better. Bone density...

     The New England Journal of Medicine, 2006 · 144 people

   • Frail older women given DHEA along with gentle exercise got a little stronger in the legs. Bone density did not change over six months. Small and short. Everyone exercised, so this compares DHEA plus exercise against exercise alone.

     Journal of the American Geriatrics Society, 2010 · 99 people

4. 04SermorelinPeptideModerate. At least one finished study in people, and at least 100 people who took it. 3 completed trials, 139 people given it.8 reported

   19 people1 study1 found nothing

   • found nothingThe hormone response faded while the injections carried on. Nineteen adults aged 55 to 71 injected salt water nightly for a month, then a sermorelin-like peptide for four more months. Growth hormone and its main blood marker rose within two weeks, stayed up for three months, then drifted back to where they started...

     Journal of Clinical Endocrinology and Metabolism, 1997 · 19 people

5. 05ResveratrolSupplementModerate. At least one finished study in people, and at least 100 people who took it. 14 completed trials, 403 people given it.7 reported

   number of people not given1 study

   • The same trial found a real gain in bone. After a year on 75 mg twice daily, bone density in the lower spine rose against the dummy, the hip score improved a little, and a marker of bone being broken down fell. Estimated ten year fracture risk came down. Women with the worst bone markers gained most, as did those also...

     Journal of Bone and Mineral Research, 2020 · number of people not given

6. 06Thymalin with epitalonBlendStrong. At least two finished studies in people, and at least 1,000 people who took it. 2 completed trials, 1,106 people given it.7 reported

   number of people not given1 study

   • This is the study the thymalin story rests on, and it is not built to carry that weight. 266 older people were followed for six to eight years, and given thymalin and epithalamin in the first two or three. Infections and deaths were reported at about half the rate of a comparison group, and several age-related...

     Neuro Endocrinology Letters, 2003 · number of people not given

7. 07MK-677Small moleculeLimited. People have taken it in a published study, but fewer than 100 of them. 2 completed trials, 65 people given it.11 reported

   number of people not given1 study

   • The trial was stopped early over a heart safety signal, and most of what it measured did not improve. 123 older people recovering from a broken hip took MK-677 or a dummy pill. Walking speed improved and IGF-1 rose. Most other measures of function did not move. The study was halted before it finished because of...

     Archives of Gerontology and Geriatrics, 2011 · number of people not given

8. 08OxandroloneHormonePreliminary. Studied in people, but no published study has had people take it. 1 human study where nobody was given it.5 reported

   number of people not given1 study

   • Oxandrolone left badly burned children with stronger bones five years later. 119 children with burns over 30 percent of their body got the drug twice a day for up to two years, or a dummy pill. Treated children had stronger bones across the whole body and lower spine, and grew taller faster early on. Fewer had bones...

     Shock, 2016 · number of people not given

9. 09Vitamin K2SupplementPreliminary. Studied in people, but no published study has had people take it. 2 human studies where nobody was given it.1 reported

   number of people not given1 study

   • Healthy women past menopause who took a low dose of K2 for three years lost less bone. That is bone density, not broken bones, and it was not a test of living longer.

     Osteoporosis International, 2013 · number of people not given

10. 10Nandrolone decanoateHormoneLimited. People have taken it in a published study, but fewer than 100 of them. 3 completed trials, none stating how many people.6 reported

    number of people not given0 studies

1. 01Botulinum toxin type ABiologicStrong. At least two finished studies in people, and at least 1,000 people who took it. 2 completed trials, 1,681 people given it.5 reported

   1,384 people1 study

   • Botulinum toxin cut chronic migraine days, and the dummy injections cut them almost as much. 1,384 adults were injected with either the toxin or a dummy every twelve weeks across two trials. After six months, headache days had fallen by about eight a month on the toxin and about seven on the dummy. The gap between...

     Headache, 2010 · 1,384 people

2. 02PT-141PeptideStrong. At least two finished studies in people, and at least 1,000 people who took it. 4 completed trials, 2,355 people given it.9 reported

   1,267 people1 study

   • It raised sexual desire in women by a small but real amount, and made a lot of them feel sick. 1,267 premenopausal women with low sexual desire used bremelanotide as needed, or a dummy injection, over about six months across two matching trials. Desire scores rose and distress about low desire fell, more than on the...

     Obstetrics & Gynecology, 2019 · 1,267 people

3. 03Melanotan IIPeptideStrong. At least two finished studies in people, and at least 1,000 people who took it. 5 completed trials, 1,310 people given it.9 reported

   1,267 people1 study

   • The owned descendant of this chemistry was tested properly, and it worked a little. Two large trials gave bremelanotide or a dummy injection to 1,267 women before menopause who had lost interest in sex. Desire rose and distress fell on the drug, by a real but small margin. Nausea, flushing and headache were all...

     Obstetrics and Gynecology, 2019 · 1,267 people

4. 04Relaxin-2PeptideStrong. At least two finished studies in people, and at least 1,000 people who took it. 2 completed trials, 7,706 people given it.5 reported

   1,161 people1 study1 found nothing

   • found nothingSerelaxin eased breathlessness a little in people admitted with sudden heart failure, and changed nothing that matters more. 1,161 people got either a two day drip of the drug or a dummy drip soon after reaching hospital. Breathlessness scored better on one scale and no better on the other. Deaths from heart causes...

     The Lancet, 2013 · 1,161 people

5. 05CGRPPeptideModerate. At least one finished study in people, and at least 100 people who took it. 2 completed trials, 968 people given it.

   968 people2 studies

   • The money in this peptide is in blocking it, and blocking it clearly works. 955 people with migraine got a monthly shot of one of two erenumab doses, or a dummy shot, for six months. They started with roughly eight migraine days a month. On the drug they lost between three and four of those days. On the dummy they...

     The New England Journal of Medicine, 2017 · 955 people

   • Give a person this peptide and it gives them a migraine. Thirteen migraine patients each got CGRP on one day and a dummy infusion on another, without being told which was which. Ten of the thirteen developed a migraine-like attack on CGRP. Nobody did on the dummy. The headaches were worse and they lasted longer. That...

     The Journal of Headache and Pain, 2018 · 13 people

6. 06CebranopadolSmall moleculeModerate. At least one finished study in people, and at least 100 people who took it. 5 completed trials, 300 people given it.

   258 people2 studies1 found nothing

   • found nothingOne tablet beat both a dummy and morphine for pain after foot surgery. Two hundred and fifty eight patients got cebranopadol at one of three strengths, a slow release morphine tablet, or a dummy. The two higher strengths relieved pain over the first ten hours better than either comparison. Morphine worked, but later....

     Pain Physician, 2018 · 258 people

   • This trial never got the people it needed and it did not show what it set out to show. It was built for more than five hundred patients with cancer pain and recruited a quarter of that before stopping. Those who took part got cebranopadol or slow release morphine for up to seven weeks. People on cebranopadol reached...

     European Journal of Pain, 2019 · number of people not given

7. 07Carbetocin (intranasal)PeptideModerate. At least one finished study in people, and at least 100 people who took it. 3 completed trials, 343 people given it.

   175 people1 study

   • This was the trial that settled the question, and carbetocin failed it. 175 people with Prader-Willi syndrome used either a carbetocin nasal spray or a dummy spray, three times a day for 12 weeks. The relentless hunger that defines the condition eased by the same amount in both groups, with the dummy group very...

     Clinical Therapeutics, 2026 · 175 people

8. 08ZiconotidePeptideModerate. At least one finished study in people, and at least 100 people who took it. 2 completed trials, 111 people given it.2 reported

   111 people2 studies

   • Ziconotide clearly relieved severe pain that nothing else was touching. 111 people with cancer or AIDS, aged 24 to 85, got either the drug or a dummy into the fluid around the spinal cord, and nobody involved knew which. Pain scores dropped by about half on the drug and by under a fifth on the dummy. Just over half...

     JAMA, 2004 · 111 people

   • The drug worked for long term pain not caused by cancer, and the dose had to be cut mid trial to make it bearable. 255 hospital inpatients got ziconotide or a dummy into the spinal fluid over six days. Pain fell by about a third on the drug and by a twentieth on the dummy. Partway through, side effects forced the team...

     Neuromodulation, 2006 · number of people not given

9. 09Alpha-2-MacroglobulinBiologicLimited. People have taken it in a published study, but fewer than 100 of them. 1 completed trial, 75 people given it.6 reported

   75 people1 study1 found nothing

   • found nothingA2M injections helped knees, but no better than the cheaper options they were tested against. 75 people with moderate knee osteoarthritis were split by chance between an A2M-rich concentrate, ordinary platelet-rich plasma, and a steroid injection. Nobody involved knew which. 68 finished. At 12 weeks the A2M group had...

     Bulletin of the Hospital for Joint Diseases, 2024 · 75 people

10. 10MelittinPeptideModerate. At least one finished study in people, and at least 100 people who took it. 5 completed trials, 658 people given it.4 reported

    54 people1 study

    • A small study found less back pain after bee venom acupuncture. Fifty four people with long standing low back pain had six sessions over three weeks, either the real thing or a fake version, on top of a painkiller everyone took. Pain, bother and function all improved more in the venom group at three weeks. Fifty four...

      Toxins, 2017 · 54 people

11. 11MifepristoneSmall moleculeModerate. At least one finished study in people, and at least 100 people who took it. 2 completed trials, 320 people given it.4 reported

    50 people1 study

    • In Cushing's syndrome, where cortisol is the problem, blocking its receptor with mifepristone improved blood sugar, blood pressure and weight over six months. 50 adults took part, and there was no dummy pill group. Tiredness, nausea, headache and low potassium were common. This is the approved use, not a study of...

      The Journal of Clinical Endocrinology and Metabolism, 2012 · 50 people

12. 12CoQ10SupplementModerate. At least one finished study in people, and at least 100 people who took it. 2 completed trials, 162 people given it.4 reported

    42 people1 study

    • CoQ10 cut migraine attacks in a small trial that is not about ageing. 42 people took 100 mg three times a day, or a dummy. By the third month, 47.6 percent on CoQ10 had half as many attacks, against 14.4 percent on the dummy. That is a migraine result in 42 people.

      Neurology, 2005 · 42 people

13. 13BPC-157PeptideLimited. People have taken it in a published study, but fewer than 100 of them. 3 completed trials, 31 people given it.10 reported

    17 people1 study

    • This is not a trial, and it cannot show the peptide helped anyone. Doctors at one Florida clinic looked back through the records of 17 patients who had been injected in the knee. They phoned 16 of them six to twelve months later and asked how the knee felt. Of the 12 given BPC-157 on its own, 11 said the pain was...

      Alternative Therapies in Health and Medicine, 2021 · 17 people

14. 14DSIPPeptideLimited. People have taken it in a published study, but fewer than 100 of them. 6 completed trials, 7 people given it.8 reported

    7 people1 study

    • Pain fell in six of seven people, and there was nobody to compare them with. Seven patients with migraine, headache, long standing tinnitus or unexplained pain attacks got DSIP into a vein, daily for five days and then every few days. Their pain scores fell against their own earlier readings, and their low mood lifted...

      European Neurology, 1984 · 7 people

15. 15Collagen peptidesSupplementLimited. People have taken it in a published study, but fewer than 100 of them. 2 completed trials, 69 people given it.4 reported

    number of people not given1 study1 found nothing

    • found nothingCollagen did not beat a dummy for knee pain in a study nobody selling collagen paid for. Both groups got better, by roughly 1.6 to 1.9 points on the pain scale. That is a bigger improvement than the gap industry funded trials credit to collagen itself. Read that carefully. People improved, and collagen was not the...

      Applied Physiology, Nutrition, and Metabolism, 2020 · number of people not given

16. 16SS-20PeptideAnimal or lab only. Only animal or lab studies on this page. No study in people yet. 4 animal studies, 1 lab study, no human study.6 reported

    number of people not given0 studies

    • In mice. Mice on a weekly cancer drug got nerve pain and lost tiny nerve fibres in their paws. A steady supply of SS-20 prevented the pain and kept the nerve fibres normal. It was given to prevent the damage, not to treat it. The authors declare a money interest, and nobody has followed this up in people.

      ACS Chemical Neuroscience, 2018 · number of people not given

17. 17Thymosin Alpha-1PeptideStrong. At least two finished studies in people, and at least 1,000 people who took it. 2 completed trials, 1,204 people given it.7 reported

    number of people not given0 studies
18. 18MOTS-cPeptideLimited. People have taken it in a published study, but fewer than 100 of them. 1 completed trial, 30 people given it.6 reported

    number of people not given0 studies
19. 19HumaninPeptideLimited. People have taken it in a published study, but fewer than 100 of them. 1 completed trial, 30 people given it.6 reported

    number of people not given0 studies
20. 20Thymosin Beta-4PeptideStrong. At least two finished studies in people, and at least 1,000 people who took it. 5 completed trials, 1,382 people given it.9 reported

    number of people not given0 studies
21. 21NoopeptSmall moleculeLimited. People have taken it in a published study, but fewer than 100 of them. 1 completed trial, none stating how many people.5 reported

    number of people not given0 studies
22. 22NattokinaseBiologicStrong. At least two finished studies in people, and at least 1,000 people who took it. 9 completed trials, 1,795 people given it.6 reported

    number of people not given0 studies
23. 23LamivudineSmall moleculeLimited. People have taken it in a published study, but fewer than 100 of them. 1 completed trial, none stating how many people.3 reported

    number of people not given0 studies
24. 24ClenbuterolSmall moleculeLimited. People have taken it in a published study, but fewer than 100 of them. 2 completed trials, 11 people given it.5 reported

    number of people not given0 studies