Should tirzepatide be cycled?

Its FDA labels answer this directly. Tirzepatide (Mounjaro, Zepbound) is approved as continuous once-weekly treatment for as long as the labeled condition is being managed. The label does not include an off period. Community protocols that stop and restart it as a cycle are unverified. This site does not invent a schedule. Stopping is a clinical decision with the prescriber, not a forum calendar. Full detail at /cycling.

Full cycling page: what is measured versus assumed

Educational use only. This database summarizes published research and is not medical advice. Where a dose appears it is a record of what a trial or clinic ran, or what people describe doing, with its source attached. Nothing here is a recommendation for personal use.

Part of cycling and clearance. Whether peptides need a break, what a half-life actually tells you, and where a real cycling mechanism has been measured. Full detail at /cycling.