Should sermorelin be cycled?
Studies in people do not establish an on and off schedule for sermorelin. It works through the same GHRH receptor where, in other studies in people, a steady signal partly dulled the response within hours. So the body can get used to drugs in this family. But nobody has compared a sermorelin cycle to steady use. The schedules passed around online are unverified. This site does not invent a schedule. When sermorelin was an approved product (Geref), children with growth hormone deficiency got it daily for as long as they needed treatment, not on a cycle the user picked. Full detail at /cycling.
Full cycling page: what was tested versus assumed
Studies in people from the compound pages this answer belongs to
- Sermorelin
- Growth hormone (GH)-releasing hormone-(1-29) twice daily reverses the decreased GH and insulin-like growth factor-I levels in old men 1992 PMID 1379256
- Once daily subcutaneous growth hormone-releasing hormone therapy accelerates growth in growth hormone-deficient children during the first year of therapy. Geref International Study Group 1996 PMID 8772599
- Endocrine and metabolic effects of long-term administration of [Nle27]growth hormone-releasing hormone-(1-29)-NH2 in age-advanced men and women 1997 PMID 9141536
Educational use only. This database summarizes published research and is not medical advice. Where a dose appears it is a record of what a trial or clinic ran, or what people describe doing, with its source attached. Nothing here is a recommendation for personal use.
Part of cycling and clearance. Whether peptides need a break, what a half-life actually tells you, and where a real cycling mechanism has been measured. Full detail at /cycling.