Should semaglutide be cycled?
Its FDA labels answer this. Semaglutide (Ozempic, Wegovy) is approved as a once-weekly treatment without breaks, for as long as type 2 diabetes or long-term weight management is being treated. The label has no time off. The follow-up to the STEP 1 study measured what stopping does: about two thirds of the lost weight came back within a year. The schedules passed around online that cycle it are unverified. This site does not invent a schedule. Coming off is a medical decision. Full detail at /cycling.
Full cycling page: what was tested versus assumed
Studies in people from the compound pages this answer belongs to
- Semaglutide
- Semaglutide and Cardiovascular Outcomes in Obesity without Diabetes (SELECT) 2023 PMID 37952131
- Once-Weekly Semaglutide in Adults with Overweight or Obesity (STEP 1) 2021 PMID 33567185
- Efficacy and safety of oral semaglutide 14 mg (flexible dose) in early-stage symptomatic Alzheimer's disease (evoke and evoke+): two phase 3, randomised, placebo-controlled trials 2026 PMID 41865758
Educational use only. This database summarizes published research and is not medical advice. Where a dose appears it is a record of what a trial or clinic ran, or what people describe doing, with its source attached. Nothing here is a recommendation for personal use.
Part of cycling and clearance. Whether peptides need a break, what a half-life actually tells you, and where a real cycling mechanism has been measured. Full detail at /cycling.