What happens when you come off a GLP-1?

Stopping has been measured for semaglutide. In the STEP 1 trial extension, people who stopped after 68 weeks regained about two thirds of the weight they had lost within a year. That is the underlying condition returning once the drug's effect ends, not a withdrawal syndrome, and nothing measured got worse than baseline. It is the evidence-based reason those drugs are approved for continuous use rather than a cycle. Coming off is a clinical decision with a prescriber, not a forum off-week. Aaron is a coach, not a doctor. This site does not invent a taper. Full detail at /cycling.

Full cycling page: what is measured versus assumed

Educational use only. This database summarizes published research and is not medical advice. Where a dose appears it is a record of what a trial or clinic ran, or what people describe doing, with its source attached. Nothing here is a recommendation for personal use.

Part of cycling and clearance. Whether peptides need a break, what a half-life actually tells you, and where a real cycling mechanism has been measured. Full detail at /cycling.