What happens when you come off a GLP-1?

Stopping has been measured for semaglutide. In the follow-up to the STEP 1 study, people who stopped after 68 weeks gained back about two thirds of the weight they had lost within a year. That is the original condition coming back once the drug wears off. It is not a withdrawal problem, and nothing measured got worse than where people started. It is the evidence-based reason these drugs are approved for use without breaks, not in cycles. Coming off is a medical decision to make with your prescriber, not a forum week off. Aaron is a coach, not a doctor. This site does not invent a taper. Full detail at /cycling.

Full cycling page: what was tested versus assumed

Educational use only. This database summarizes published research and is not medical advice. Where a dose appears it is a record of what a trial or clinic ran, or what people describe doing, with its source attached. Nothing here is a recommendation for personal use.

Part of cycling and clearance. Whether peptides need a break, what a half-life actually tells you, and where a real cycling mechanism has been measured. Full detail at /cycling.