Peptide finder

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Pick as many as you like. The number on each one is how many people it has been measured in across the whole archive. So you can see where the evidence is before you choose.

1. 01TesamorelinPeptideStrong. At least two finished studies in people, and at least 1,000 people who took it. 8 completed trials, 1,729 people given it.10 reported

   152 people1 study

   • Thinking scores edged up, and this was one modest trial. 152 adults aged 55 to 87 took tesamorelin or a dummy injection daily for about five months. Sixty six of them already had mild memory problems. The drug group did a little better at tests of planning and mental flexibility, by enough to separate from chance....

     Archives of Neurology, 2012 · 152 people

2. 02Tesamorelin / IpamorelinBlendStrong. At least two finished studies in people, and at least 1,000 people who took it. 5 completed trials, 1,507 people given it.9 reported

   152 people1 study

   • A low dose of tesamorelin nudged thinking in the right direction in older adults. A hundred and fifty two people aged 55 to 87 took it or a dummy shot for five months, and sixty six of them already had mild memory trouble. The gain showed up mainly in planning and mental flexibility. IGF-1 more than doubled while...

     Archives of Neurology, 2012 · 152 people

3. 03SermorelinPeptideModerate. At least one finished study in people, and at least 100 people who took it. 3 completed trials, 139 people given it.8 reported

   139 people3 studies1 found nothing

   • Children with a growth hormone deficiency grew faster on sermorelin, in a study with nobody to compare them against. 110 children injected it nightly for up to a year. Their growth roughly doubled, from about four centimetres a year to eight at six months, settling near seven by a year. About three quarters responded...

     Journal of Clinical Endocrinology and Metabolism, 1996 · 110 people

   • found nothingThe hormone response faded while the injections carried on. Nineteen adults aged 55 to 71 injected salt water nightly for a month, then a sermorelin-like peptide for four more months. Growth hormone and its main blood marker rose within two weeks, stayed up for three months, then drifted back to where they started...

     Journal of Clinical Endocrinology and Metabolism, 1997 · 19 people

   • A short course of injections put older men's growth hormone back to young-adult levels. 10 healthy older men injected this fragment of growth hormone releasing hormone twice a day for 14 days. Their growth hormone across a full day, and their IGF-1, rose to levels that could not be told apart from young men's. Ten men...

     Journal of Clinical Endocrinology & Metabolism, 1992 · 10 people

4. 04OctreotidePeptideModerate. At least one finished study in people, and at least 100 people who took it. 2 completed trials, 140 people given it.3 reported

   115 people1 study

   • In acromegaly the drug brought the hormone down in about half the patients. A hundred and fifteen people with the condition, which is caused by too much growth hormone, were treated across several hospitals. Growth hormone fell below the target level in 53 of every 100, and IGF-1 came back to normal in 68 of every...

     Annals of Internal Medicine, 1992 · 115 people

5. 05HexarelinPeptideModerate. At least one finished study in people, and at least 100 people who took it. 6 completed trials, 105 people given it.7 reported

   112 people5 studies

   • The older you are, the less growth hormone hexarelin gets out of you. 60 people across four age groups each got a single dose into a vein. Young adults released nearly twice as much growth hormone as elderly people, 1,829.7 against 951.1 in the units used. The stress hormone response went the other way, trending...

     European Journal of Endocrinology, 1997 · 60 people

   • Body fat blunts the response, so the heavier you are the less hexarelin does. 21 healthy elderly people each got a single shot under the skin. The more fat someone carried, the lower their growth hormone peak, and fat mass predicted the response better than anything else measured. Being male or female made no...

     Clinical Endocrinology, 1998 · 21 people

   • As a pituitary test hexarelin works for growth hormone and fails for cortisol. 19 patients were tested both with hexarelin and with the old method of driving blood sugar down with insulin. Hexarelin pushed growth hormone far higher, 67.1 against 26.9 mU/L, and the two tests agreed on whether growth hormone was normal...

     Clinical Endocrinology, 1999 · 19 people

6. 06MecaserminPeptideLimited. People have taken it in a published study, but fewer than 100 of them. 1 completed trial, 76 people given it.6 reported

   200,535 people5 studies

   • Men with naturally higher IGF-1 in their blood get prostate cancer somewhat more often. Nearly 200,000 men were followed for about seven years. 5,402 were diagnosed with prostate cancer and 295 died of it. The higher a man's level, the higher his risk, and a genetic analysis pointed the same way, which makes a real...

     International Journal of Cancer, 2021 · 199,698 people

   • Low blood sugar is the main hazard of this treatment, and this registry shows how often it actually happens. 306 patients were tracked from 2008 to 2021, most of them with severe IGF-1 deficiency. 80 had at least one low blood sugar episode and 224 had none. Serious episodes were rare. Children who had low blood sugar...

     Journal of Clinical Endocrinology and Metabolism, 2023 · 306 people

   • The treatment helps children who do not have Laron syndrome as well, just less. 242 children across ten European countries were entered in an ongoing registry. Among the 138 never treated before, first year height gain was bigger in the 21 with Laron syndrome than in the 117 without. Even so, more than half the non...

     European Journal of Endocrinology, 2021 · 242 people

7. 07MK-677Small moleculeLimited. People have taken it in a published study, but fewer than 100 of them. 2 completed trials, 65 people given it.11 reported

   65 people2 studies1 found nothing

   • found nothingIt shifted muscle and fat, and it did not make anyone stronger or more able. 65 adults aged 60 to 81 took MK-677 or a dummy pill daily for up to two years. Growth hormone and IGF-1 climbed back to young-adult levels. Lean tissue rose about 1.1 kg while the dummy group lost about half a kilo. Strength and everyday...

     Annals of Internal Medicine, 2008 · 65 people

   • The trial was stopped early over a heart safety signal, and most of what it measured did not improve. 123 older people recovering from a broken hip took MK-677 or a dummy pill. Walking speed improved and IGF-1 rose. Most other measures of function did not move. The study was halted before it finished because of...

     Archives of Gerontology and Geriatrics, 2011 · number of people not given

8. 08MK-677 with ipamorelinBlendModerate. At least one finished study in people, and at least 100 people who took it. 2 completed trials, 182 people given it.7 reported

   65 people1 study

   • MK-677 worked in the longest study any of these drugs has had, and the gains were modest. 65 healthy adults aged 60 to 81 took a 25 mg pill or a dummy pill every day for two years. Nobody knew which they had. Growth hormone and IGF-1 climbed back into the range of a healthy young adult, with no serious harms. Lean...

     Annals of Internal Medicine, 2008 · 65 people

9. 09SomatropinBiologicLimited. People have taken it in a published study, but fewer than 100 of them. 2 completed trials, 84 people given it.9 reported

   60 people1 study

   • Take growth hormone away from adults who need it and most things get worse. 60 adults with a pituitary shortage, treated for about ten years, were switched onto a dummy for four months. Their IGF-1 fell sharply. Two aspects of quality of life declined. Waists grew, deep belly fat rose, and cholesterol and an...

     Journal of Clinical Endocrinology and Metabolism, 2012 · 60 people

10. 10Sermorelin / GHRPBlendLimited. People have taken it in a published study, but fewer than 100 of them. 4 completed trials, 56 people given it.9 reported

    63 people4 studies1 found nothing

    • found nothingOld pituitaries answered the combined signal as well as young ones did. Twenty six healthy people aged 19 to 96 were given both peptides together into a vein, once. Growth hormone rose sharply in every one of them, and the size of the rise did not fall off with age. That is worth knowing, because age is usually blamed...

      Journal of Clinical Endocrinology and Metabolism, 1998 · 26 people

    • Adding a releasing hormone to a ghrelin type drug roughly doubled the growth hormone response. Twenty patients were tested on two separate days, once with one drug and once with both. In people with a healthy pituitary the peak went from 25.7 to 54.7 units, and in people short of the hormone from 1.3 to 4.0. Flushing...

      European Journal of Endocrinology, 2002 · 20 people

    • Sermorelin lifted old men's growth hormone back to a young man's level, at a dose far above what people inject now. Ten healthy older men took it twice a day for two weeks. By the end, their growth hormone and IGF-1 across a full day matched those of young men. Ten men for two weeks tells you the hormone moved. It...

      Journal of Clinical Endocrinology and Metabolism, 1992 · 10 people

11. 11Ursolic acidSupplementLimited. People have taken it in a published study, but fewer than 100 of them. 1 completed trial, 16 people given it.6 reported

    16 people1 study1 found nothing

    • found nothingThe entire human record for ursolic acid is sixteen men. 16 healthy men averaging 29 did eight weeks of weight training, seven on training alone and nine also taking ursolic acid capsules three times a day. Body fat percentage fell in the supplemented group. Body weight, body mass index, muscle mass, blood sugar and...

      Korean Journal of Physiology and Pharmacology, 2014 · 16 people

12. 12GHRP-2PeptideModerate. At least one finished study in people, and at least 100 people who took it. 3 completed trials, 102 people given it.7 reported

    15 people1 study1 found nothing

    • found nothingChildren given GHRP-2 up the nose grew faster, and the study had nothing to compare them against. Fifteen short children took it twice and later three times a day for months. Their growth rate rose from under four centimetres a year to about six. The blood marker usually treated as the sign of a growth hormone effect...

      Journal of Endocrinology, 1997 · 15 people

13. 13GalaninPeptideLimited. People have taken it in a published study, but fewer than 100 of them. 4 completed trials, 21 people given it.

    13 people3 studies3 found nothing

    • found nothingGalanin shuts down insulin in dogs and rodents, and in people it did nothing of the kind. Seven healthy men were given a sugar load on its own, and again with galanin at two high infusion rates. Blood sugar and insulin came out the same either way, though growth hormone still rose. The authors' own conclusion is the...

      Diabetes, 1989 · 7 people

    • found nothingHuman galanin drove growth hormone up eightfold and left the pancreas completely alone. Six healthy volunteers were infused for an hour while their blood sugar was deliberately held high. Insulin, glucagon and blood sugar behaved exactly as they had without it. The body cleared half the galanin in under four minutes,...

      Diabetologia, 1993 · 6 people

    • found nothingThe first time galanin was given to people, it set off a surge of growth hormone. Ten healthy volunteers were infused for an hour at one of two rates. Growth hormone climbed many times over, further at the higher rate. The hormone behind milk production rose a little. Stress and thyroid hormones did not move, and...

      The Lancet, 1986 · number of people not given

14. 14GHRP-6PeptideLimited. People have taken it in a published study, but fewer than 100 of them. 5 completed trials, 42 people given it.8 reported

    9 people1 study1 found nothing

    • found nothingThe longest anyone has been kept on this peptide, and the response was already fading by the end. Nine healthy young men had GHRP-6 or salt water dripped in for thirty-four hours. Total growth hormone output roughly doubled and IGF-1 rose modestly. The natural pulse pattern did not change. By the end the pituitary was...

      Journal of Clinical Endocrinology and Metabolism, 1993 · 9 people

15. 15CJC-1295PeptideLimited. People have taken it in a published study, but fewer than 100 of them. 2 completed trials, none stating how many people.9 reported

    number of people not given2 studies1 found nothing

    • One shot lifted growth hormone for over a week, and that is the whole of what was measured. Healthy adults got a single injection of CJC-1295 or a dummy injection, and nobody involved knew which. Growth hormone in the blood then ran two to ten times higher for six days or more. IGF-1, the hormone the liver makes in...

      Journal of Clinical Endocrinology & Metabolism, 2006 · number of people not given

    • found nothingThe drug lifted growth hormone without flattening the body's own rhythm. Healthy men got a single dose. A week later their lowest growth hormone readings were about seven and a half times higher than before, average growth hormone was up by roughly half, and IGF-1 was up by roughly half. The pulses the body normally...

      Journal of Clinical Endocrinology & Metabolism, 2006 · number of people not given

16. 16AOD-9604PeptideLimited. People have taken it in a published study, but fewer than 100 of them. 1 completed trial, none stating how many people.5 reported

    number of people not given1 study1 found nothing

    • found nothingAOD9604 was tested properly for weight loss and it did not work. Six separate trials compared it with a dummy, and none of them delivered the fat loss the drug was built for. It did not change the growth hormone marker in the blood, and it did not change how people handled sugar. Its side effect profile looked the...

      Journal of Endocrinology and Metabolism, 2013 · number of people not given

17. 17Modified GRF 1-29PeptideLimited. People have taken it in a published study, but fewer than 100 of them. 1 completed trial, none stating how many people.9 reported

    number of people not given1 study

    • The peptide did move hormone levels, and this trial tested a different version from the one usually sold. Healthy adults aged 21 to 61 got either rising doses or a dummy, with nobody knowing which. A single injection pushed growth hormone several fold higher for six days or more, and IGF-1 stayed up for a week and a...

      Journal of Clinical Endocrinology and Metabolism, 2006 · number of people not given

18. 18CJC-1295 / IpamorelinBlendLimited. People have taken it in a published study, but fewer than 100 of them. 2 completed trials, 20 people given it.9 reported

    number of people not given1 study

    • One injection kept growth hormone raised for the better part of a week. Healthy adults were given a single shot of CJC-1295 or a dummy shot, and their blood was tracked afterwards. Growth hormone ran several times higher for six days or more, and IGF-1, the hormone it drives, stayed up for nine to eleven days. The...

      Journal of Clinical Endocrinology and Metabolism, 2006 · number of people not given

19. 19CJC-1295 with GHRP-2BlendLimited. People have taken it in a published study, but fewer than 100 of them. 2 completed trials, none stating how many people.8 reported

    number of people not given1 study

    • Putting the two drug types together does push growth hormone higher than either one alone. Healthy older adults got GHRH, GHRP-2, or both, through a drip over 24 hours. The pair beat each drug on its own. The extra boost from pairing them was three times bigger in young people than in older ones. It was bigger in...

      Journal of Clinical Endocrinology and Metabolism, 2004 · number of people not given

20. 20CJC-1295 with GHRP-6BlendLimited. People have taken it in a published study, but fewer than 100 of them. 2 completed trials, 9 people given it.7 reported

    number of people not given1 study

    • A single shot of the long-acting version lifts growth hormone for days in healthy adults. That much is solid. Growth hormone ran two to ten times above its usual level for six days or more. The growth factor IGF-1 stayed high for nine to eleven days. Half a dose is still in the body a week later. Read the label with...

      Journal of Clinical Endocrinology and Metabolism, 2006 · number of people not given

21. 21CJC-1295 with ipamorelin and GHRP-2BlendModerate. At least one finished study in people, and at least 100 people who took it. 2 completed trials, 117 people given it.5 reported

    number of people not given2 studies

    • A single shot of the long-acting version keeps growth hormone up for days. Here that is the problem, not the selling point. In healthy adults growth hormone ran two to ten times above its usual level for six days or more. IGF-1 stayed high for nine to eleven days. After repeat doses, IGF-1 was still above where it...

      Journal of Clinical Endocrinology and Metabolism, 2006 · number of people not given

    • One hunger-hormone type peptide plus GHRH is enough to show the effect. That is the point to take from this study. Healthy older adults given the pair through a 24 hour drip made more growth hormone than with either drug alone. Nobody has tested adding a second peptide that presses the same switch as the first....

      Journal of Clinical Endocrinology and Metabolism, 2004 · number of people not given

22. 22DermorphinPeptideLimited. People have taken it in a published study, but fewer than 100 of them. 1 completed trial, 11 people given it.2 reported

    11 people1 study

    • Again a probe of how the pituitary gland works, not a treatment. Eleven people with a hormone producing tumour in the pituitary were given dermorphin. Prolactin did not budge in any of them, unlike in healthy people. Growth hormone rose in everyone except the three with the largest tumours. The point was to learn...

      Metabolism, 1985 · 11 people

23. 23Sermorelin with ipamorelinBlendModerate. At least one finished study in people, and at least 100 people who took it. 1 completed trial, 117 people given it.8 reported

    number of people not given2 studies

    • Sermorelin was put head to head with growth hormone itself, in children who were short of it. That is the sort of evidence behind sermorelin's approval as a medicine. Be clear about who was studied. These were children with a diagnosed hormone shortage, treated so they would grow. They were not healthy adults hoping...

      Acta Paediatrica Supplement, 1993 · number of people not given

    • The two-switch idea behind this vial has worked in people, but with different drugs. Healthy older adults given a hunger-hormone type peptide together with GHRH made more growth hormone than with either one alone. That is the best proof that pairing the two kinds does something real. It is not proof for this product....

      Journal of Clinical Endocrinology and Metabolism, 2004 · number of people not given

24. 24OxandroloneHormonePreliminary. Studied in people, but no published study has had people take it. 1 human study where nobody was given it.5 reported

    number of people not given1 study

    • Oxandrolone left badly burned children with stronger bones five years later. 119 children with burns over 30 percent of their body got the drug twice a day for up to two years, or a dummy pill. Treated children had stronger bones across the whole body and lower spine, and grew taller faster early on. Fewer had bones...

      Shock, 2016 · number of people not given

1. 01TestosteroneHormoneModerate. At least one finished study in people, and at least 100 people who took it. 1 completed trial, 5,246 people given it.10 reported

   5,246 people2 studies1 found nothing

   • Testosterone did not raise the risk of heart attacks or strokes in the men most likely to have one. More than 5,000 men aged 45 to 80 took part. All had low testosterone with symptoms, and all were already at risk of heart trouble. Half rubbed on a testosterone gel and half a dummy gel. After about three years, heart...

     New England Journal of Medicine, 2023 · 5,246 people

   • found nothingTestosterone helped older men with sex and did much less for everything else. It raised their levels to what a man in his twenties or thirties would have. Sex drive, sexual activity and erections all clearly got better. Energy did not get better at all. Walking distance only improved when three studies were lumped...

     New England Journal of Medicine, 2016 · number of people not given

2. 02Testosterone cypionateHormoneModerate. At least one finished study in people, and at least 100 people who took it. 1 completed trial, 5,246 people given it.9 reported

   5,246 people1 study

   • The one large safety study found no extra heart attacks, strokes or heart deaths on testosterone. More than 5,000 men took part, all already at risk of heart trouble. It is here because it is the best safety proof any testosterone product has. Note what it tested. Men rubbed on a gel that doctors adjusted to a set...

     New England Journal of Medicine, 2023 · 5,246 people

3. 03TriptorelinPeptideStrong. At least two finished studies in people, and at least 1,000 people who took it. 4 completed trials, 1,388 people given it.5 reported

   1,388 people3 studies

   • Triptorelin reliably shuts testosterone down in men with advanced prostate cancer. Researchers pooled 920 men from nine studies and tracked testosterone for a year. About eight in ten were fully suppressed after one month, and about nine in ten from three months onward. This adds up nine studies. It is not one study...

     Advances in Therapy, 2017 · 920 people

   • This trial is about when to give radiotherapy, not about triptorelin, and it found no advantage in giving it early. Triptorelin was the hormone treatment handed to both groups, so it was never the thing being tested. 424 men who had had prostate surgery were assigned to immediate radiotherapy or to waiting until their...

     The Lancet Oncology, 2020 · 424 people

   • The six month injection held back puberty in children who had started it far too early. 44 children who had never been treated, 39 girls and five boys, were given the long acting form across 18 centres. By six months, 41 of them had hormone levels back in the prepubertal range, and by a year almost all did. Everybody...

     Journal of Pediatric Endocrinology and Metabolism, 2016 · 44 people

4. 04DegarelixPeptideModerate. At least one finished study in people, and at least 100 people who took it. 2 completed trials, 610 people given it.3 reported

   610 people1 study

   • Degarelix shut testosterone down as well as the older drug and did it far faster. 610 men with prostate cancer, typically in their early seventies, got one of two degarelix schedules or a monthly leuprolide injection. By a year, nearly all men in every group were fully suppressed. The difference showed at day three,...

     BJU International, 2008 · 610 people

5. 05LeuprolidePeptideModerate. At least one finished study in people, and at least 100 people who took it. 2 completed trials, 199 people given it.3 reported

   199 people1 study

   • It matched the older treatment and was far easier to live with. A hundred and ninety nine men with prostate cancer that had spread took either leuprolide or the oestrogen drug used at the time. Both shut testosterone down about as well. The men on leuprolide had much less breast growth, sickness and swelling, and far...

     New England Journal of Medicine, 1984 · 199 people

6. 06DHEAHormoneModerate. At least one finished study in people, and at least 100 people who took it. 3 completed trials, 267 people given it.5 reported

   168 people2 studies1 found nothing

   • found nothingThe biggest study of DHEA against a dummy pill as an anti-ageing supplement found nothing that mattered. 144 older men and women with low levels took it for two years. The hormone went up and little else changed. Body shape, strength, fitness, blood sugar control and quality of life did not get better. Bone density...

     The New England Journal of Medicine, 2006 · 144 people

   • In women whose adrenal glands make no DHEA, replacing it helped mood and sexual interest. 24 women took DHEA for four months and a dummy pill for four months. It is a study of people who lack the hormone, not of ageing.

     The New England Journal of Medicine, 1999 · 24 people

7. 07GonadorelinPeptideModerate. At least one finished study in people, and at least 100 people who took it. 3 completed trials, 110 people given it.8 reported

   110 people3 studies

   • Pulsed gonadorelin brought hormones back in nearly every man, but fertility depended on his history. 76 men missing a hormone signal wore a pump that gave a small dose every one to two hours for up to two years. Testosterone and the pituitary signal came back to normal in almost all. Men who had been through some...

     Journal of Clinical Endocrinology and Metabolism, 2002 · 76 people

   • The pump got sperm going sooner, but no more men got there in the end. 28 men producing no sperm were compared: 10 wore a gonadorelin pump and 18 took the usual hormone injections. Nobody was assigned by chance, so the groups were not built alike. First sperm appeared at about six months on the pump against fourteen...

     American Journal of Men's Health, 2019 · 28 people

   • Given the way the body gives it, in pulses from a pump, gonadorelin restarted puberty in men whose brains were not signalling. Six men with this condition wore a pump delivering small doses under the skin. Their pituitary hormones were normal within a week. Testosterone rose from 77 to 520 units over a month, into the...

     New England Journal of Medicine, 1982 · 6 people

8. 08ForskolinSupplementLimited. People have taken it in a published study, but fewer than 100 of them. 2 completed trials, 53 people given it.5 reported

   30 people1 study

   • Body fat fell and testosterone rose, in thirty overweight men. The men all had a body mass index of 26 or above and took 250 mg of a 10 percent forskolin extract twice a day, or a dummy, decided by chance, for 12 weeks. Scans showed body fat percentage and fat mass dropped against the dummy group. Bone mass changed...

     Obesity Research, 2005 · 30 people

9. 09HCGBiologicLimited. People have taken it in a published study, but fewer than 100 of them. 2 completed trials, 55 people given it.8 reported

   29 people1 study

   • A small shot of hCG kept the testicles working while men were on testosterone. Twenty nine healthy men had their own hormone signal switched off by testosterone, which normally shuts the testicles down. Those also given a low dose of hCG every other day held testosterone inside the testicle near normal. That is a...

     Journal of Clinical Endocrinology and Metabolism, 2005 · 29 people

10. 10Kisspeptin-10PeptideLimited. People have taken it in a published study, but fewer than 100 of them. 4 completed trials, 44 people given it.8 reported

    11 people3 studies

    • This study used kisspeptin-54, which is a different molecule from the kisspeptin-10 people buy. It was the first time any kisspeptin was given to humans. Six men received a 90 minute drip, and the two pituitary hormones that drive the testes went up, and so did testosterone. Six men is a very small group, everybody...

      Journal of Clinical Endocrinology and Metabolism, 2005 · 6 people

    • The same dose of kisspeptin-10 does completely different things in men and women. In men, a single injection raised the hormones that drive the testes at very low doses. In women in the first half of their cycle, nothing happened, even at much higher doses given three different ways. In women close to ovulation, the...

      Journal of Clinical Endocrinology and Metabolism, 2011 · 5 people

    • Kisspeptin-10 switches on the hormone system that drives testosterone. Healthy men were given a single injection into a vein, and the pituitary hormone that tells the testes to work tripled within half an hour. A longer drip lasting most of a day raised that hormone and testosterone, and made the natural pulses come...

      Journal of Clinical Endocrinology and Metabolism, 2011 · number of people not given

11. 11CetrorelixPeptideModerate. At least one finished study in people, and at least 100 people who took it. 1 completed trial, 564 people given it.3 reported

    number of people not given1 study

    • In fertility treatment the newer drug did the same job with less of everything. Women having their ovaries stimulated were split by chance between cetrorelix and the older drug, buserelin. Cetrorelix stopped the early hormone surge that ruins an egg collection cycle, with a surge in only 1.6 of every hundred women....

      Human Reproduction, 2000 · number of people not given

12. 12EnclomipheneSmall moleculePreliminary. Studied in people, but no published study has had people take it. 1 human study where nobody was given it.6 reported

    number of people not given1 study

    • Enclomiphene raised testosterone without flattening sperm counts, which is the whole point of it. In a mid-sized trial it was compared with testosterone gel rubbed on the skin. Men on enclomiphene ended up with more testosterone and kept their sperm counts. Testosterone treatment itself tends to push sperm counts down.

      Fertility and Sterility, 2014 · number of people not given

13. 13FOXO4-DRIPeptideLimited. People have taken it in a published study, but fewer than 100 of them. 1 completed trial, 74 people given it.8 reported

    number of people not given0 studies

    • In mice. A separate lab found the same effect. In old mice it cleared worn-out testosterone-making cells and raised testosterone.

      Aging, 2020 · number of people not given

14. 1417-alpha-estradiolHormoneAnimal or lab only. Only animal or lab studies on this page. No study in people yet. 4 animal studies, no human study.4 reported

    number of people not given0 studies

    • In mice, a higher dose worked even better, but still only in males. At three times the earlier dose, male mice lived longer on average, and the longest-lived ones lived longer too. The same paper found NDGA and Protandim also helped male mice. Fish oil, a bile acid drug and metformin on its own did not help. Metformin...

      Aging Cell, 2016 · number of people not given

15. 15NDGASupplementAnimal or lab only. Only animal or lab studies on this page. No study in people yet. 2 animal studies, no human study.4 reported

    number of people not given0 studies

    • In mice, this is the first report of the male-leaning lifespan result. NDGA, acarbose and 17-alpha-estradiol all helped males more than females.

      Aging Cell, 2014 · number of people not given

16. 16NRPTSupplementModerate. At least one finished study in people, and at least 100 people who took it. 3 completed trials, 176 people given it.3 reported

    number of people not given0 studies

    • found nothingIn mice. In the US government mouse testing program, mixed-breed mice fed nicotinamide riboside from 8 months old did not live longer, male or female, across three labs. In the same group, a drug called 17-alpha-estradiol made males live 19 percent longer on average. That shows the test could spot a big effect.

      Aging Cell, 2021 · number of people not given

17. 17OsteocalcinPeptidePreliminary. Studied in people, but no published study has had people take it. 2 human studies where nobody was given it.

    number of people not given0 studies

    • In mice. A new strain made without osteocalcin had normal bone amount, blood sugar, testosterone and muscle mass. What was off was the lining up of bone's mineral crystals, and the bones got weaker. The authors conclude osteocalcin does not act as a hormone.

      PLoS Genetics, 2020 · number of people not given

18. 18Urolithin BSupplementLimited. People have taken it in a published study, but fewer than 100 of them. 1 completed trial, none stating how many people.

    number of people not given0 studies

    • In mouse muscle cells in a dish and in mice. Urolithin B made the cells grow, through more protein building and less protein breakdown, and the androgen receptor was involved. In mice, a nonstop dose from a pump under the skin for 28 days made muscles bigger and cut wasting after nerve injury. Not a dose by mouth, and...

      Journal of Cachexia, Sarcopenia and Muscle, 2017 · number of people not given

19. 19EnobosarmSmall moleculeModerate. At least one finished study in people, and at least 100 people who took it. 1 completed trial, 159 people given it.5 reported

    number of people not given0 studies
20. 20OxandroloneHormonePreliminary. Studied in people, but no published study has had people take it. 1 human study where nobody was given it.5 reported

    number of people not given0 studies
21. 21Nandrolone decanoateHormoneLimited. People have taken it in a published study, but fewer than 100 of them. 3 completed trials, none stating how many people.6 reported

    number of people not given0 studies
22. 22TUDCASupplementLimited. People have taken it in a published study, but fewer than 100 of them. 3 completed trials, 54 people given it.7 reported

    number of people not given0 studies
23. 23Kisspeptin-54PeptideModerate. At least one finished study in people, and at least 100 people who took it. 5 completed trials, 122 people given it.8 reported

    number of people not given0 studies
24. 24GHRP-2PeptideModerate. At least one finished study in people, and at least 100 people who took it. 3 completed trials, 102 people given it.7 reported

    number of people not given0 studies

1. 01Melanotan IIPeptideStrong. At least two finished studies in people, and at least 1,000 people who took it. 5 completed trials, 1,310 people given it.9 reported

   30 people2 studies

   • This pools every man the Arizona group ever dosed, and it comes to twenty. Across two studies, seventeen of the twenty had an erection with no sexual stimulation at all, lasting about forty minutes at useful firmness. They also reported wanting sex more often on the drug than on the dummy injection. Severe nausea hit...

     International Journal of Impotence Research, 2000 · 20 people

   • Melanotan II produced erections in men with erectile dysfunction, and made several of them badly sick. Ten men took both the drug and a dummy injection on separate occasions, and nobody involved knew which was which on the day. They reported an erection after most of the drug injections and after one of the dummy...

     Urology, 2000 · 10 people

2. 02SermorelinPeptideModerate. At least one finished study in people, and at least 100 people who took it. 3 completed trials, 139 people given it.8 reported

   19 people1 study1 found nothing

   • found nothingThe hormone response faded while the injections carried on. Nineteen adults aged 55 to 71 injected salt water nightly for a month, then a sermorelin-like peptide for four more months. Growth hormone and its main blood marker rose within two weeks, stayed up for three months, then drifted back to where they started...

     Journal of Clinical Endocrinology and Metabolism, 1997 · 19 people

3. 03Melanotan II with PT-141BlendLimited. People have taken it in a published study, but fewer than 100 of them. 3 completed trials, 10 people given it.7 reported

   number of people not given1 study

   • The same kind of peptide also worked in men whose erection trouble had a physical cause, which is the harder group to help. Men got the drug or a dummy by chance, and both erections and sexual desire got better. This was another small study. The usual problems of this drug family came with it: nausea, flushing and...

     Urology, 2000 · number of people not given

4. 04PT-141 with oxytocinBlendLimited. People have taken it in a published study, but fewer than 100 of them. 3 completed trials, 10 people given it.6 reported

   number of people not given1 study

   • Oxytocin was tested properly for sex problems in women, and it did not beat a dummy spray. Thirty women used an oxytocin nasal spray or a dummy spray before sex. Each tried both over 22 weeks, and nobody knew which was which. Sexual function scores rose 26% on oxytocin and 31% on the dummy. Distress about sex fell 36%...

     Fertility and Sterility, 2015 · number of people not given

5. 05TestosteroneHormoneModerate. At least one finished study in people, and at least 100 people who took it. 1 completed trial, 5,246 people given it.10 reported

   number of people not given1 study1 found nothing

   • found nothingTestosterone helped older men with sex and did much less for everything else. It raised their levels to what a man in his twenties or thirties would have. Sex drive, sexual activity and erections all clearly got better. Energy did not get better at all. Walking distance only improved when three studies were lumped...

     New England Journal of Medicine, 2016 · number of people not given

6. 06GalaninPeptideLimited. People have taken it in a published study, but fewer than 100 of them. 4 completed trials, 21 people given it.

   number of people not given0 studies

   • In rats, plus nerve cells in a dish. Galanin partly restored erections after a nerve injury and helped nerves regrow in a dish. It is here because this rat result gets passed around without anyone saying it was rats.

     The Journal of Sexual Medicine, 2018 · number of people not given

7. 07OxytocinPeptideModerate. At least one finished study in people, and at least 100 people who took it. 2 completed trials, 290 people given it.5 reported

   number of people not given0 studies
8. 08HexarelinPeptideModerate. At least one finished study in people, and at least 100 people who took it. 6 completed trials, 105 people given it.7 reported

   number of people not given0 studies
9. 09Kisspeptin-10PeptideLimited. People have taken it in a published study, but fewer than 100 of them. 4 completed trials, 44 people given it.8 reported

   number of people not given0 studies
10. 10HCGBiologicLimited. People have taken it in a published study, but fewer than 100 of them. 2 completed trials, 55 people given it.8 reported

    number of people not given0 studies
11. 11EnclomipheneSmall moleculePreliminary. Studied in people, but no published study has had people take it. 1 human study where nobody was given it.6 reported

    number of people not given0 studies
12. 12EcdysteroneSupplementModerate. At least one finished study in people, and at least 100 people who took it. 3 completed trials, 233 people given it.5 reported

    number of people not given0 studies
13. 13OxandroloneHormonePreliminary. Studied in people, but no published study has had people take it. 1 human study where nobody was given it.5 reported

    number of people not given0 studies
14. 14Nandrolone decanoateHormoneLimited. People have taken it in a published study, but fewer than 100 of them. 3 completed trials, none stating how many people.6 reported

    number of people not given0 studies
15. 15SimvastatinSmall moleculeStrong. At least two finished studies in people, and at least 1,000 people who took it. 2 completed trials, 24,980 people given it.6 reported

    number of people not given0 studies
16. 16Botulinum toxin type ABiologicStrong. At least two finished studies in people, and at least 1,000 people who took it. 2 completed trials, 1,681 people given it.5 reported

    number of people not given0 studies
17. 17Kisspeptin-54PeptideModerate. At least one finished study in people, and at least 100 people who took it. 5 completed trials, 122 people given it.8 reported

    number of people not given0 studies
18. 18Omega-3SupplementStrong. At least two finished studies in people, and at least 1,000 people who took it. 3 completed trials, 34,050 people given it.4 reported

    number of people not given0 studies

1. 01AlbiglutideBiologicStrong. At least two finished studies in people, and at least 1,000 people who took it. 2 completed trials, 10,304 people given it.

   9,463 people1 study

   • Albiglutide cut heart attacks, strokes and cardiac deaths in people with diabetes and heart disease. Nearly ten thousand adults across 28 countries were split by chance between the drug and a dummy injection, and followed for about a year and a half. Nobody involved knew which. Seven in a hundred on the drug had a...

     Lancet, 2018 · 9,463 people

2. 02GHRP-6PeptideLimited. People have taken it in a published study, but fewer than 100 of them. 5 completed trials, 42 people given it.8 reported

   27 people2 studies2 found nothing

   • found nothingThe first clean human demonstration that this peptide releases growth hormone, and it does. 18 healthy men got GHRP-6 into a vein at three dose levels. Growth hormone peaked far higher than on the dummy and climbed steeply with dose. At half doses it worked with the natural releasing hormone to do more than either...

     Journal of Clinical Endocrinology and Metabolism, 1990 · 18 people

   • found nothingThe longest anyone has been kept on this peptide, and the response was already fading by the end. Nine healthy young men had GHRP-6 or salt water dripped in for thirty-four hours. Total growth hormone output roughly doubled and IGF-1 rose modestly. The natural pulse pattern did not change. By the end the pituitary was...

     Journal of Clinical Endocrinology and Metabolism, 1993 · 9 people

3. 03ForskolinSupplementLimited. People have taken it in a published study, but fewer than 100 of them. 2 completed trials, 53 people given it.5 reported

   23 people1 study1 found nothing

   • found nothingThe same supplement was tested in women and it did not work. 23 mildly overweight women took a 10 percent Coleus forskohlii extract twice a day or a dummy for 12 weeks, seven on the extract. Fat mass, lean mass and body fat percentage came out the same in both groups. Slight leanings toward less weight gain were too...

     Journal of the International Society of Sports Nutrition, 2005 · 23 people

4. 04LeptinBiologicModerate. At least one finished study in people, and at least 100 people who took it. 6 completed trials, 844 people given it.5 reported

   3 people1 study

   • Give leptin to the rare children who have none and it transforms them. Three children born unable to make leptin were injected daily for up to four years. Appetite fell, fat mass fell, insulin and blood fats came back towards normal, and puberty arrived at the right age. Immune cells that had been depleted recovered...

     Journal of Clinical Investigation, 2002 · 3 people

5. 05BPC-157PeptideLimited. People have taken it in a published study, but fewer than 100 of them. 3 completed trials, 31 people given it.10 reported

   2 people1 study1 found nothing

   • found nothingA study this small cannot show that anything is safe. Two healthy adults were given BPC-157 into a vein, 10 mg on the first day and 20 mg on the second. Neither reported side effects, and blood tests covering the heart, liver, kidneys, thyroid and blood sugar did not shift. That is worth knowing, and it is all it is....

     Alternative Therapies in Health and Medicine, 2025 · 2 people

6. 06GalaninPeptideLimited. People have taken it in a published study, but fewer than 100 of them. 4 completed trials, 21 people given it.

   number of people not given1 study1 found nothing

   • found nothingThe first time galanin was given to people, it set off a surge of growth hormone. Ten healthy volunteers were infused for an hour at one of two rates. Growth hormone climbed many times over, further at the higher rate. The hormone behind milk production rose a little. Stress and thyroid hormones did not move, and...

     The Lancet, 1986 · number of people not given

7. 07AshwagandhaSupplementLimited. People have taken it in a published study, but fewer than 100 of them. 1 completed trial, none stating how many people.2 reported

   number of people not given1 study

   • Adults who took a strong root extract felt less stressed than those on a dummy pill. This measured how people felt, not how long they lived or their thyroid health.

     Indian Journal of Psychological Medicine, 2012 · number of people not given

8. 08TUDCASupplementLimited. People have taken it in a published study, but fewer than 100 of them. 3 completed trials, 54 people given it.7 reported

   number of people not given0 studies