How does cortexin work?

Cortexin is a mixture of low-molecular-weight peptides extracted from the cerebral cortex of cattle. This site's profile proposes neurotrophic signaling and neuroprotection. Half-life varies because it is a mixture. There is no single molecular weight. The one human citation on that page is a Russian clinical study of repeated low-dose Cortexin courses in hemispheric ischemic stroke, not independently replicated outside that tradition. It is used clinically in Russia and nearby countries and is not FDA approved. A 2021 rodent comparison found Cortexin showed neuroprotective activity in acute and chronic ischemia models against Cerebrolysin and Actovegin. Those animal findings do not transfer into a counted Western stroke result. This FAQ does not invent a human mechanism. Full record at /compounds/cortexin.

Educational use only. This database summarizes published research and is not medical advice. Where a dose appears it is a record of what a trial or clinic ran, or what people describe doing, with its source attached. Nothing here is a recommendation for personal use.

Part of cognitive and mood peptides. Selank, semax, cerebrolysin, and other nootropic and CNS peptides.