How does dihexa work?

Dihexa is a small peptide made from angiotensin IV, a piece of a blood pressure hormone. This site's profile says it boosts a growth signal (HGF) and its receptor (c-Met) to help brain cells form new connections. It is listed as leaving the body quickly (a short half-life). Its molecular weight is about 564 daltons. Another name is PNB-0408. This site's review found no human clinical trials. The 2013 paper that introduced dihexa carries an Expression of Concern from the journal. Three related papers from the same lab on how it works are marked retracted on PubMed. It is not FDA approved. In rats, the 2013 paper reported that it reversed memory loss caused by a drug (scopolamine) and grew more connections in the brain's memory center. Those animal findings do not transfer into a counted human cognitive result, and the paper it all rests on is under journal concern. This FAQ does not invent a human mechanism. Full record at /compounds/dihexa.

Educational use only. This database summarizes published research and is not medical advice. Where a dose appears it is a record of what a trial or clinic ran, or what people describe doing, with its source attached. Nothing here is a recommendation for personal use.

Part of cognitive and mood peptides. Selank, semax, cerebrolysin, and other nootropic and CNS peptides.