How does dihexa work?

Dihexa is a small peptide derived from angiotensin IV. This site's profile says it potentiates hepatocyte growth factor and its c-Met receptor to drive synaptogenesis. Half-life is listed as short. Molecular weight is about 564 daltons. Alias: PNB-0408. This site's review found no human clinical trials. The 2013 paper that introduced dihexa carries an Expression of Concern. Three companion papers from the same laboratory on the HGF/c-Met mechanism are marked retracted on PubMed. It is not FDA approved. The 2013 paper reported reversal of scopolamine-induced memory deficits and increased hippocampal synaptogenesis in rats. Those animal findings do not transfer into a counted human cognitive result, and the foundational file is under journal concern. This FAQ does not invent a human mechanism. Full record at /compounds/dihexa.

Educational use only. This database summarizes published research and is not medical advice. Where a dose appears it is a record of what a trial or clinic ran, or what people describe doing, with its source attached. Nothing here is a recommendation for personal use.

Part of cognitive and mood peptides. Selank, semax, cerebrolysin, and other nootropic and CNS peptides.