How does selank work?

Selank is a synthetic analogue of tuftsin. This site's profile says it modulates GABA and monoamine systems and influences enkephalin degradation and BDNF expression, producing anxiolytic effects. Half-life is short, on the order of minutes; it is used intranasally. Molecular weight is 751.9 daltons. The one human citation on that page is a 62-patient Russian study of generalized anxiety disorder or neurasthenia randomized to Selank (n=30) or medazepam (n=32): anxiolytic effects were similar, and Selank additionally showed anti-asthenic and psychostimulant effects. There was no dummy arm. It is approved in Russia and not FDA approved. Animal citations on that page report anti-stress effects of Selank and related tuftsin-family peptides in rats and mice. Those animal findings do not transfer into a counted Western replication. This FAQ does not invent a dose. Full record at /compounds/selank.

Educational use only. This database summarizes published research and is not medical advice. Where a dose appears it is a record of what a trial or clinic ran, or what people describe doing, with its source attached. Nothing here is a recommendation for personal use.

Part of cognitive and mood peptides. Selank, semax, cerebrolysin, and other nootropic and CNS peptides.