How does davunetide work?

Davunetide is an eight-amino-acid piece of a brain-protecting protein called ADNP. This site's profile says it steadies the inner support tubes (microtubules) and tau-linked framework inside nerve cells. It is listed as leaving the body quickly (a short half-life). Its molecular weight is about 827 daltons. Other names are NAP and AL-108. A 52-week study in 313 people with progressive supranuclear palsy (a rare brain disease) found people on davunetide did no better than people on a dummy treatment, on the disease rating scale or on a daily-living scale. A schizophrenia study found it was well tolerated. It did not really change scores on a thinking test (MCCB). There was a small hint of better everyday functioning (UPSA), but that was not the main question. It is not approved. A failed key study is the record in people, not a thinking result this FAQ will invent. This FAQ does not invent a dose. Full record at /compounds/davunetide.

Educational use only. This database summarizes published research and is not medical advice. Where a dose appears it is a record of what a trial or clinic ran, or what people describe doing, with its source attached. Nothing here is a recommendation for personal use.

Part of cognitive and mood peptides. Selank, semax, cerebrolysin, and other nootropic and CNS peptides.