How does DSIP work?
This site's DSIP profile says the exact receptor targets remain unclear. It is a nine-amino-acid peptide with a molecular weight of 848.9 daltons, and the body clears it quickly, in minutes. A 2006 review cited on that page says the link to sleep was never pinned down: nobody found a gene, a parent molecule, or a receptor for it. So the sleep idea is still weak. This site's review found no published study in people. In July 2026 the Pharmacy Compounding Advisory Committee voted against recommending DSIP, also called emideltide, for compounding. Having sleep in the name is not a counted sleep effect. This FAQ does not invent a receptor. Full record at /compounds/dsip.
Studies in people from the compound pages this answer belongs to
- DSIP
- Effects of delta sleep-inducing peptide on sleep of chronic insomniac patients. A double-blind study 1992 PMID 1299794
- Study of delta sleep-inducing peptide efficacy in improving sleep on short-term administration to chronic insomniacs 1987 PMID 3583493
- Effects of delta-sleep-inducing peptide on 24-hour sleep-wake behaviour in severe chronic insomnia 1987 PMID 3622582
Educational use only. This database summarizes published research and is not medical advice. Where a dose appears it is a record of what a trial or clinic ran, or what people describe doing, with its source attached. Nothing here is a recommendation for personal use.
Part of cognitive and mood peptides. Selank, semax, cerebrolysin, and other nootropic and CNS peptides.