How does setmelanotide work?

Setmelanotide is a selective MC4R agonist. This site's profile says it restores satiety signaling disrupted by upstream genetic defects in the melanocortin pathway. Half-life is about 11 hours. Molecular weight is 1,117.3 daltons. It is FDA approved as Imcivree for obesity caused by POMC, PCSK1, or LEPR deficiency, and later for Bardet-Biedl syndrome. In the Phase 3 trials, 8 of 10 participants with POMC deficiency and 5 of 11 with LEPR deficiency lost at least 10% of body weight at about one year, with hunger scores down 27% and 44%; hyperpigmentation and injection-site reactions were near-universal. In Bardet-Biedl syndrome, 32.3% of those aged 12 or older reached at least 10% weight loss at 52 weeks. It is not a general weight-loss drug. A research-chemical vial is not Imcivree. This FAQ does not invent a dose. Full record at /compounds/setmelanotide.

Educational use only. This database summarizes published research and is not medical advice. Where a dose appears it is a record of what a trial or clinic ran, or what people describe doing, with its source attached. Nothing here is a recommendation for personal use.

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