How does setmelanotide work?

Setmelanotide switches on only the MC4R receptor. This site's profile says it restores the fullness signal that is broken by certain gene defects further up the melanocortin pathway. The body clears half of it in about 11 hours. Its molecular weight is 1,117.3 daltons. It is FDA approved as Imcivree for obesity caused by POMC, PCSK1, or LEPR deficiency, and later for Bardet-Biedl syndrome. In the large final-stage studies, 8 of 10 people with POMC deficiency and 5 of 11 with LEPR deficiency lost at least 10% of body weight at about one year, with hunger scores down 27% and 44%. Nearly everyone had skin darkening and reactions where it was injected. In Bardet-Biedl syndrome, 32.3% of those aged 12 or older lost at least 10% at 52 weeks. It is not a general weight-loss drug. A research-chemical vial is not Imcivree. This FAQ does not invent a dose. Full record at /compounds/setmelanotide.

Educational use only. This database summarizes published research and is not medical advice. Where a dose appears it is a record of what a trial or clinic ran, or what people describe doing, with its source attached. Nothing here is a recommendation for personal use.

Part of sexual health and hormone peptides. PT-141, melanotan, oxytocin, gonadorelin, and kisspeptin-10.