How does gonadorelin work?
Gonadorelin is a lab-made copy of gonadotropin-releasing hormone (GnRH), the brain signal that drives LH and FSH from the pituitary gland. This site's profile says the body clears half of it in about 2 to 4 minutes. Its molecular weight is 1,182.3 daltons. It has to be given in pulses. Steady exposure wears out the pituitary and shuts hormone release down, which is how drugs like leuprolide turn the system off. In six men with low sex hormones caused by a brain signal problem, GnRH given in pulses under the skin by a pump brought LH and FSH to normal within a week. It raised testosterone from 77 to 520 ng/dL in one month, and three of the six began making sperm. Its old FDA approvals for testing and fertility have mostly been dropped. Compounding and off-label use to support testosterone replacement are a different route from those dropped products. This FAQ does not invent a dose. Full record at /compounds/gonadorelin.
Studies in people from the compound pages this answer belongs to
- Gonadorelin
- Induction of puberty in men by long-term pulsatile administration of low-dose gonadotropin-releasing hormone 1982 PMID 6813732
- Predictors of outcome of long-term GnRH therapy in men with idiopathic hypogonadotropic hypogonadism. 2002 PMID 12213860
- The Pulsatile Gonadorelin Pump Induces Earlier Spermatogenesis Than Cyclical Gonadotropin Therapy in Congenital Hypogonadotropic Hypogonadism Men. 2019 PMID 30569789
Educational use only. This database summarizes published research and is not medical advice. Where a dose appears it is a record of what a trial or clinic ran, or what people describe doing, with its source attached. Nothing here is a recommendation for personal use.
Part of sexual health and hormone peptides. PT-141, melanotan, oxytocin, gonadorelin, and kisspeptin-10.