Is gonadorelin the same as kisspeptin-10?
No. Kisspeptin-10 acts one step earlier. It prompts the body to release its own GnRH. Gonadorelin is lab-made GnRH given directly. Kisspeptin-10's profile lists a molecular weight of about 1,302 daltons, and a study where one dose into a vein tripled LH in healthy men. Gonadorelin's profile lists a molecular weight of 1,182.3 daltons, a half-life of 2 to 4 minutes, and a six-man pump study that gave it in pulses and raised testosterone from 77 to 520 ng/dL. Acting on the same hormone chain does not make them the same molecule, and they are not dosed the same way: gonadorelin has to be given in pulses or it shuts the pituitary down. This site does not rank them. Full records at /compounds/gonadorelin and /compounds/kisspeptin-10.
Studies in people from the compound pages this answer belongs to
- Kisspeptin-10
- Gonadorelin
- Induction of puberty in men by long-term pulsatile administration of low-dose gonadotropin-releasing hormone 1982 PMID 6813732
- Predictors of outcome of long-term GnRH therapy in men with idiopathic hypogonadotropic hypogonadism. 2002 PMID 12213860
- The Pulsatile Gonadorelin Pump Induces Earlier Spermatogenesis Than Cyclical Gonadotropin Therapy in Congenital Hypogonadotropic Hypogonadism Men. 2019 PMID 30569789
Educational use only. This database summarizes published research and is not medical advice. Where a dose appears it is a record of what a trial or clinic ran, or what people describe doing, with its source attached. Nothing here is a recommendation for personal use.
Part of sexual health and hormone peptides. PT-141, melanotan, oxytocin, gonadorelin, and kisspeptin-10.