Is metastin the same as kisspeptin-54?
Yes. Metastin is another name listed on this site's kisspeptin-54 profile, along with KP-54. It names the same 54-building-block product of the KISS1 gene, roughly 6 kilodaltons in size, that latches onto KISS1R on the brain cells that make GnRH. The IVF egg-trigger program at Imperial used kisspeptin-54. It matured eggs in 95% of 60 women at high risk of ovarian hyperstimulation syndrome (a dangerous overreaction to fertility drugs), with no moderate, severe, or critical cases. Metastin is not kisspeptin-10, the 10-amino-acid piece sold as a research chemical. The names are aliases of the longer peptide, not a US approval. Full record at /compounds/kisspeptin-54.
Studies in people from the compound pages this answer belongs to
- Kisspeptin-54
- Efficacy of Kisspeptin-54 to Trigger Oocyte Maturation in Women at High Risk of Ovarian Hyperstimulation Syndrome (OHSS) During In Vitro Fertilization (IVF) Therapy 2015 PMID 26192876
- A second dose of kisspeptin-54 improves oocyte maturation in women at high risk of ovarian hyperstimulation syndrome: a Phase 2 randomized controlled trial 2017 PMID 28854728
- Subcutaneous injection of kisspeptin-54 acutely stimulates gonadotropin secretion in women with hypothalamic amenorrhea, but chronic administration causes tachyphylaxis 2009 PMID 19820030
Educational use only. This database summarizes published research and is not medical advice. Where a dose appears it is a record of what a trial or clinic ran, or what people describe doing, with its source attached. Nothing here is a recommendation for personal use.
Part of sexual health and hormone peptides. PT-141, melanotan, oxytocin, gonadorelin, and kisspeptin-10.