How does melanotan 2 work?
Melanotan II, also listed as MT-II, switches on melanocortin receptors broadly: MC1R for melanin and skin color, and MC4R for brain pathways that affect appetite and sexual function. This site's profile says the body clears half of it in about 1 hour. Its molecular weight is 1,024.2 daltons. A study in ten men with erectile dysfunction caused by the mind, where each man tried both the drug and a dummy, produced visible erections in eight of the ten. Nausea, stretching, and yawning were more common than on the dummy. A two-week pilot in three men produced tanning, nausea at most doses, and erections that came on their own and lasted 1 to 5 hours. One case report describes new odd-looking moles in a man who had had melanoma, while he was injecting himself with a related alpha-MSH drug. It is not approved in the US, UK, Australia, or Canada, and Australia bans its supply. This FAQ does not invent a dose. Full record at /compounds/melanotan-2.
Studies in people from the compound pages this answer belongs to
- Melanotan II
- Evaluation of melanotan-II, a superpotent cyclic melanotropic peptide in a pilot phase-I clinical study 1996 PMID 8637402
- Synthetic melanotropic peptide initiates erections in men with psychogenic erectile dysfunction: double-blind, placebo controlled crossover study 1998 PMID 9679884
- Alpha-melanocyte-stimulating hormone-induced eruptive nevi 2009 PMID 19380666
Educational use only. This database summarizes published research and is not medical advice. Where a dose appears it is a record of what a trial or clinic ran, or what people describe doing, with its source attached. Nothing here is a recommendation for personal use.
Part of sexual health and hormone peptides. PT-141, melanotan, oxytocin, gonadorelin, and kisspeptin-10.