Does PT-141 really work?
It is FDA approved as Vyleesi, only for low sexual desire that causes distress (hypoactive sexual desire disorder) in women who have not reached menopause. That approval rests on studies with more than 1,200 people, so it is a real approval, not a marketing claim. It works through the brain's melanocortin system, not through blood flow like erectile dysfunction drugs. That is also why its most common side effects, nausea and flushing, differ from those drugs.
Studies in people from the compound pages this answer belongs to
- PT-141
- Bremelanotide for the Treatment of Hypoactive Sexual Desire Disorder: Two Randomized Phase 3 Trials (RECONNECT) 2019 PMID 31599840
- Long-Term Safety and Efficacy of Bremelanotide for Hypoactive Sexual Desire Disorder 2019 PMID 31599847
- Usefulness of ambulatory blood pressure monitoring to assess the melanocortin receptor agonist bremelanotide 2017 PMID 27977473
Educational use only. This database summarizes published research and is not medical advice. Where a dose appears it is a record of what a trial or clinic ran, or what people describe doing, with its source attached. Nothing here is a recommendation for personal use.
Part of sexual health and hormone peptides. PT-141, melanotan, oxytocin, gonadorelin, and kisspeptin-10.