Does PT-141 lose effectiveness with repeated use?

This site does not hold a study that measures the body getting used to PT-141, or a date when it stops working for a person. RECONNECT tested 1.75 milligrams, taken as needed, in 1,267 women with low sexual desire that causes distress, who had not reached menopause, over 24 weeks. Desire scores rose by 0.35 on a desire questionnaire (the FSFI desire scale) compared with a dummy shot. Nausea, flushing, and headache each showed up in 10% or more. The 52-week follow-on in 684 women, where everyone knew they were getting the drug, only tracked safety. So it cannot show that the effect still beats a dummy shot. Use in men is off-label. A research-chemical vial is not the labeled Vyleesi product. This FAQ does not invent a fade clock. Talk with a clinician if the approved product is not doing what you expected. Full record at /compounds/pt-141.

Educational use only. This database summarizes published research and is not medical advice. Where a dose appears it is a record of what a trial or clinic ran, or what people describe doing, with its source attached. Nothing here is a recommendation for personal use.

Part of sexual health and hormone peptides. PT-141, melanotan, oxytocin, gonadorelin, and kisspeptin-10.