How does kisspeptin-54 work?

Kisspeptin-54 is the 54-building-block product of the KISS1 gene. This site's profile says it latches onto KISS1R (once called GPR54) on the brain cells that make GnRH. That makes the body release its own GnRH, which drives two pituitary hormones, LH and FSH. That LH response has been measured directly in studies in people, with the peptide given under the skin, into a vein, and up the nose. Its size is roughly 6 kilodaltons. A mid-stage study of 60 women at high risk of ovarian hyperstimulation syndrome (a dangerous overreaction to fertility drugs) found eggs matured in 95%. Across 51 embryo transfers, early pregnancy, confirmed pregnancy, and live birth rates were 63%, 53%, and 45%, with no moderate, severe, or critical overreaction. A second-dose study in 62 women got more eggs. Giving it long-term causes tachyphylaxis, meaning the body stops responding. A 2025 study found sex hormones rose and anxiety did not change. There is no approved kisspeptin product. Those IVF numbers belong to kisspeptin-54, not kisspeptin-10. In adult male rats, long-term shots of kisspeptin-54 under the skin damaged the testicles. That animal finding does not transfer into a counted human male-use result. This FAQ does not invent a dose. Full record at /compounds/kisspeptin-54.

Educational use only. This database summarizes published research and is not medical advice. Where a dose appears it is a record of what a trial or clinic ran, or what people describe doing, with its source attached. Nothing here is a recommendation for personal use.

Part of sexual health and hormone peptides. PT-141, melanotan, oxytocin, gonadorelin, and kisspeptin-10.