When does semaglutide stop working?

This site does not hold a study that measures when semaglutide 'stops working' for a person, or that sets a point where the body gets used to it. What it holds is how long the studies ran: STEP 1 to 68 weeks, OASIS 4 to 64 weeks, STEP UP to 72 weeks, SELECT for heart events over about 39.8 months on average in 17,604 adults, and evoke to 104 weeks for Alzheimer's, where the drug did not slow decline. Those are how long the studies lasted, not a date after which the drug fails. Weight-loss studies measure a set period. They do not answer why one person hits a plateau.

Educational use only. This database summarizes published research and is not medical advice. Where a dose appears it is a record of what a trial or clinic ran, or what people describe doing, with its source attached. Nothing here is a recommendation for personal use.

Part of names, absences, and legal limits. Brand versus molecule, side effects this site's citations did not measure, how long the trials actually ran, what national legal-status fields can say, and why two-compound answers do not scale to a larger stack.