Is MOTS-c legal in the US?
This site's US legal field for MOTS-c is not approved, research use only. It is not an over-the-counter medicine and not an FDA approved drug. The FDA took it off its Category 2 compounding list in April 2026. In July 2026 an advisory panel voted 7 to 5 to recommend it for compounding, against the reviewers' advice. That vote does not change the field until the FDA acts. The UK, Australia, and Canada lines are not licensed or not approved, and Australia also notes a ban in sport (WADA). Sub-national detail is not in this dataset.
Legal status by country, one page per compound
Studies in people from the compound pages this answer belongs to
- MOTS-c
- A pro-diabetogenic mtDNA polymorphism in the mitochondrial-derived peptide, MOTS-c 2021 PMID 33468709
- Increased expression of the mitochondrial derived peptide, MOTS-c, in skeletal muscle of healthy aging men is associated with myofiber composition 2020 PMID 32182209
- Downregulation of circulating MOTS-c levels in patients with coronary endothelial dysfunction 2018 PMID 29242099
Educational use only. This database summarizes published research and is not medical advice. Where a dose appears it is a record of what a trial or clinic ran, or what people describe doing, with its source attached. Nothing here is a recommendation for personal use.
Part of names, absences, and legal limits. Brand versus molecule, side effects this site's citations did not measure, how long the trials actually ran, what national legal-status fields can say, and why two-compound answers do not scale to a larger stack.