Does MOTS-c burn fat?
Not as a measured result of giving MOTS-c to a person. The evidence in people on this site only watched people: blood levels, a mitochondrial gene variant in 27,527 people, and a rise in the body's own MOTS-c with exercise. A mid-stage study is still signing people up (NCT07505745). Links between blood levels and fat or metabolism are not the same as a fat-burning result after a dose. The MOTS-c weight-loss answer in this FAQ draws the same line: nobody has yet published a study of giving it to people. In mice, a study on the profile found the treatment prevented obesity on a fattening diet, working through AMPK (an energy sensor) in muscle.
Studies in people from the compound pages this answer belongs to
- MOTS-c
- A pro-diabetogenic mtDNA polymorphism in the mitochondrial-derived peptide, MOTS-c 2021 PMID 33468709
- Increased expression of the mitochondrial derived peptide, MOTS-c, in skeletal muscle of healthy aging men is associated with myofiber composition 2020 PMID 32182209
- Downregulation of circulating MOTS-c levels in patients with coronary endothelial dysfunction 2018 PMID 29242099
Educational use only. This database summarizes published research and is not medical advice. Where a dose appears it is a record of what a trial or clinic ran, or what people describe doing, with its source attached. Nothing here is a recommendation for personal use.
Part of names, absences, and legal limits. Brand versus molecule, side effects this site's citations did not measure, how long the trials actually ran, what national legal-status fields can say, and why two-compound answers do not scale to a larger stack.