How does larazotide work?

Larazotide acetate, also listed as AT-1001, is a peptide you swallow. This site's profile says it blocks zonulin, a protein that loosens the gut lining. The goal is to tighten the seals between gut cells and keep bits of gluten from getting through. It is listed as short-acting, and it works inside the gut. Its molecular weight is about 732 daltons. The final-stage study (307 people signed up) was terminated by the company, with no published result on whether it worked. A mid-stage study in 342 adults found only the 0.5 mg dose met its main goal for symptoms. Higher doses did not. In 184 people with celiac disease who were given gluten on purpose, 1 mg cut gluten symptoms and dulled the rise in celiac antibodies (anti-tTG). But a test of gut leakiness (the LAMA ratio) came out the same as the dummy pill. So the gut-lining effect it was built for was not shown there. It is not approved. This FAQ does not invent a dose. Full record at /compounds/larazotide.

Educational use only. This database summarizes published research and is not medical advice. Where a dose appears it is a record of what a trial or clinic ran, or what people describe doing, with its source attached. Nothing here is a recommendation for personal use.

Part of healing and recovery peptides. BPC-157, TB-500, GHK-Cu, and the tissue repair family, including what actually has human data.