How does tesofensine work?

Tesofensine is a small molecule, not a peptide. This site's profile says it stops the brain from clearing away three chemical messengers: noradrenaline, dopamine, and serotonin. That boosts fullness signals and cuts how much people eat. The body clears half of it in about 8 days. Its molecular weight is 381.9 daltons. It is still experimental and not FDA approved. A mid-stage study in 203 people reported 4.5%, 9.2%, and 10.6% weight loss at 24 weeks, versus 2.0% on a dummy pill. Resting heart rate went up 7.4 beats per minute at 0.5 mg. In April 2013, The Lancet published an Expression of Concern about that study. The paper has not been retracted, and it is still the main result in people on this page, labeled as such. A smaller follow-up found the weight change came mostly from less appetite and eating less, not from a measured fat-burning result. Being sold on a peptide store does not make it a peptide. This FAQ does not invent a dose. Full record at /compounds/tesofensine.

Educational use only. This database summarizes published research and is not medical advice. Where a dose appears it is a record of what a trial or clinic ran, or what people describe doing, with its source attached. Nothing here is a recommendation for personal use.

Part of glp-1 and metabolic peptides. Semaglutide, tirzepatide, retatrutide, and the rest of the incretin and glucagon receptor family.