Why does semaglutide make some people tired?

Semaglutide's most common side effects in studies are stomach and gut problems, like nausea and slow digestion. Tiredness can come with eating fewer calories and the body getting used to new appetite and blood sugar patterns. This site's review of semaglutide studies did not find tiredness measured as a main result on its own. So this is a likely knock-on effect of what the drug is known to do, not a separately recorded finding.

Educational use only. This database summarizes published research and is not medical advice. Where a dose appears it is a record of what a trial or clinic ran, or what people describe doing, with its source attached. Nothing here is a recommendation for personal use.

Part of glp-1 and metabolic peptides. Semaglutide, tirzepatide, retatrutide, and the rest of the incretin and glucagon receptor family.