Why does semaglutide make some people tired?

Semaglutide's most commonly reported trial side effects are gastrointestinal, nausea, and slowed digestion, and fatigue can accompany reduced calorie intake and the body adjusting to a new appetite and blood sugar pattern. This site's citation review for semaglutide did not find fatigue reported as a primary measured trial outcome on its own, so this is a plausible secondary effect of the drug's known actions rather than a separately documented finding.

Educational use only. This database summarizes published research and is not medical advice. Where a dose appears it is a record of what a trial or clinic ran, or what people describe doing, with its source attached. Nothing here is a recommendation for personal use.

Part of glp-1 and metabolic peptides. Semaglutide, tirzepatide, retatrutide, and the rest of the incretin and glucagon receptor family.