How does AOD-9604 work?

AOD-9604 is a modified C-terminal fragment of growth hormone, residues 177 to 191 with an added N-terminal tyrosine, also written Tyr-hGH177-191. This site's profile says it stimulates lipolysis and inhibits lipogenesis in fat cells in animal models, without meaningful effects on IGF-1 or blood glucose. Half-life is listed as short. Molecular weight is about 1,815 daltons. Six randomized, double-blind, placebo-controlled human trials summarized on that page found no effect on IGF-1 or glucose tolerance and a safety profile indistinguishable from placebo; the programme did not establish efficacy for weight loss. It is not an approved drug. GRAS notifications as a food ingredient are not a weight-loss approval. Animal citations on that page report reduced body weight and fat in obese mice and reduced weight gain in obese rats without insulin resistance. Those animal findings do not transfer into a human fat-loss result the six trials already failed to show. This FAQ does not invent a dose. Full record at /compounds/aod-9604.

Educational use only. This database summarizes published research and is not medical advice. Where a dose appears it is a record of what a trial or clinic ran, or what people describe doing, with its source attached. Nothing here is a recommendation for personal use.

Part of glp-1 and metabolic peptides. Semaglutide, tirzepatide, retatrutide, and the rest of the incretin and glucagon receptor family.