Can semaglutide cause constipation?

This site's semaglutide studies do not publish a counted constipation rate. What they do count for the gut is one group of stomach and gut side effects in OASIS 4: 74.0% of people on the drug versus 42.2% on a dummy pill. That study described them as nausea, vomiting, or diarrhea, in 307 adults over 64 weeks. STEP 1 (1,961 adults, down 14.9% at 68 weeks) and SELECT (17,604 adults, about 39.8 months on average, 20% fewer major heart events) are weight and heart results on this site, not a constipation count. A general gut effect is not the same as a constipation percentage this FAQ can quote. This FAQ does not invent a side-effect rate the studies do not contain. Gut symptoms that are new or severe belong with a clinician. Full record at /compounds/semaglutide.

Educational use only. This database summarizes published research and is not medical advice. Where a dose appears it is a record of what a trial or clinic ran, or what people describe doing, with its source attached. Nothing here is a recommendation for personal use.

Part of glp-1 and metabolic peptides. Semaglutide, tirzepatide, retatrutide, and the rest of the incretin and glucagon receptor family.