Why does retatrutide make you tired?

Retatrutide's large final-stage study reported dysesthesia, an odd tingling or numb feeling in the skin, in about 12.5% of people on its highest dose. It also had the stomach and gut effects common to this drug family, from slower digestion. This site's review did not find tiredness measured as a main result in its studies. So tiredness would come under the general effects of eating fewer calories and the drug's wider action, not a clearly recorded finding.

Educational use only. This database summarizes published research and is not medical advice. Where a dose appears it is a record of what a trial or clinic ran, or what people describe doing, with its source attached. Nothing here is a recommendation for personal use.

Part of glp-1 and metabolic peptides. Semaglutide, tirzepatide, retatrutide, and the rest of the incretin and glucagon receptor family.