Does semaglutide lose effectiveness over time?

This site holds no study that sets a date when semaglutide stops working as well for a person. SELECT followed 17,604 adults for about 39.8 months on average. It still found 20% fewer major heart events (6.5% versus 8.0%). That is a long time, but it is not a study of the effect fading. Weight studies (STEP 1 at 68 weeks, STEP UP at 72 weeks, OASIS 4 at 64 weeks) report a set time period. They do not publish a timeline for one person's body getting used to it. A plateau, a missed dose, a diet change, or a vial that is not the approved product are different problems from a proven loss of drug effect. This FAQ does not invent a fade date. A clinician can look at your actual course. Full record at /compounds/semaglutide.

Educational use only. This database summarizes published research and is not medical advice. Where a dose appears it is a record of what a trial or clinic ran, or what people describe doing, with its source attached. Nothing here is a recommendation for personal use.

Part of glp-1 and metabolic peptides. Semaglutide, tirzepatide, retatrutide, and the rest of the incretin and glucagon receptor family.