What is the difference between semaglutide, tirzepatide, and retatrutide?

Each activates one more receptor than the last: semaglutide hits only GLP-1, tirzepatide adds GIP, and retatrutide adds glucagon on top of both. In their respective trials, average weight loss has scaled up the same way: roughly 15% for semaglutide's approved dose, up to 21% for tirzepatide, and up to 28% for retatrutide's Phase 3 dose, though these come from separate trials in different populations rather than one head to head study of all three.

Educational use only. This database summarizes published research and is not medical advice. Where a dose appears it is a record of what a trial or clinic ran, or what people describe doing, with its source attached. Nothing here is a recommendation for personal use.

Part of glp-1 and metabolic peptides. Semaglutide, tirzepatide, retatrutide, and the rest of the incretin and glucagon receptor family.