Does semaglutide work for weight loss?

Yes, in large randomized trials against placebo. This is one of the best evidenced compounds this site tracks, with citations covering more than 17,000 participants. It is FDA approved specifically for chronic weight management as well as type 2 diabetes, and later trials have added an oral pill form and a higher injectable dose, each tested in its own randomized trial before approval.

Educational use only. This database summarizes published research and is not medical advice. Where a dose appears it is a record of what a trial or clinic ran, or what people describe doing, with its source attached. Nothing here is a recommendation for personal use.

Part of glp-1 and metabolic peptides. Semaglutide, tirzepatide, retatrutide, and the rest of the incretin and glucagon receptor family.