How does tirzepatide work?

Tirzepatide activates two receptors, GIP and GLP-1, rather than GLP-1 alone the way semaglutide does. In a head to head trial of nearly 1,900 people with type 2 diabetes, every tirzepatide dose lowered blood sugar further than semaglutide's 1 milligram dose and produced up to 5.5 kilograms more weight loss at the highest dose. That dual mechanism is the basis for its FDA approval in both diabetes and obesity.

Educational use only. This database summarizes published research and is not medical advice. Where a dose appears it is a record of what a trial or clinic ran, or what people describe doing, with its source attached. Nothing here is a recommendation for personal use.

Part of glp-1 and metabolic peptides. Semaglutide, tirzepatide, retatrutide, and the rest of the incretin and glucagon receptor family.