Is retatrutide safe?
It is still experimental, not FDA approved. So its safety record is still being built through ongoing studies, not years of real-world use. Its large final-stage study reported dysesthesia, an odd tingling or numb feeling in the skin, in about 12.5% of people on the highest dose. It also had the stomach and gut effects common to this drug family. That is real safety data from studies. It is not the full safety record from years on the market that an approved drug like semaglutide has.
Studies in people from the compound pages this answer belongs to
- Retatrutide
- Triple-Hormone-Receptor Agonist Retatrutide for Obesity: A Phase 2 Trial 2023 PMID 37366315
- Triple hormone receptor agonist retatrutide for metabolic dysfunction-associated steatotic liver disease: a randomized phase 2a trial 2024 PMID 38858523
- A Master Protocol to Investigate the Efficacy and Safety of LY3437943 Once Weekly in Participants Without Type 2 Diabetes Who Have Obesity or Overweight (TRIUMPH-1) 2026 NCT05929066
Educational use only. This database summarizes published research and is not medical advice. Where a dose appears it is a record of what a trial or clinic ran, or what people describe doing, with its source attached. Nothing here is a recommendation for personal use.
Part of glp-1 and metabolic peptides. Semaglutide, tirzepatide, retatrutide, and the rest of the incretin and glucagon receptor family.